| Long name: |
Gliomedin Primary Polyclonal Antibody |
| Also known as: |
Gliomedin PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
Gliomedin |
| Specificity: |
This is a highly specific antibody against Gliomedin |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Subcellular location: |
Extracellular |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Gliomedin/COLM |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Accumulation of Na+ channels at the nodes of Ranvier is a prerequisite for saltatory conduction, Gliomedin is a glial ligand for Neurofascin and NrCAM, Gliomedin is a single-pass type II membrane protein localized to the nodes of Ranvier and is specifically expressed in spinal cord, Gliomedin is expressed by myelinating Schwann cells and accumulates at the edges of each myelin segment during development, Gliomedin is thought to play a role in the formation of the nodes of Ranvier along myelinated axons, In peripheral nerves, It is more abundant in peripheral than central nervous system, brain, clustering of these channels along the axolemma is regulated by myelinating Schwann cells through an unknown mechanism, placenta and sciatic nerve, two axonal immunoglobulin cell adhesion molecules that are associated with Na+ channels at the nodes of Ranvier, where it aligns with the forming nodes, Gliomedin is a 551 amino acid protein encoded by the human gene GLDN |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
CLOM, COLM, CRG L2, Cancer related gene-Liver 2, Colm gene name, Colmedin, FLJ23917, GLDN_HUMAN, Gldn gene name, UNC 112, collomin, CANCER RELATED GENE LIVER 2 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Gliomedin |
| Short name: |
Gliomedin Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Gliomedin (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
29514 |
| Gene: |
GLDN |
More about : GLDN |
| Long gene name: |
gliomedin |
| Synonyms gene: |
COLM |
| Synonyms gene name: |
collomin |
| Synonyms: |
CRG-L2 CLOM colmedin UNC-112 |
| Locus: |
15q21, 2 |
| Discovery year: |
2004-05-18 |
| GenBank acession: |
AY358144 |
| Entrez gene record: |
342035 |
| Pubmed identfication: |
16039564 12642876 |
| RefSeq identity: |
NM_181789 |
| Havana BLAST/BLAT: |
OTTHUMG00000131746 |