| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Gliomedin |
| Specificity: |
This antibody reacts specifically with Gliomedin |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Gliomedin/COLM |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Accumulation of Na+ channels at the nodes of Ranvier is a prerequisite for saltatory conduction, Gliomedin is a glial ligand for Neurofascin and NrCAM, Gliomedin is a single-pass type II membrane protein localized to the nodes of Ranvier and is specifically expressed in spinal cord, Gliomedin is expressed by myelinating Schwann cells and accumulates at the edges of each myelin segment during development, Gliomedin is thought to play a role in the formation of the nodes of Ranvier along myelinated axons, In peripheral nerves, It is more abundant in peripheral than central nervous system, brain, clustering of these channels along the axolemma is regulated by myelinating Schwann cells through an unknown mechanism, placenta and sciatic nerve, two axonal immunoglobulin cell adhesion molecules that are associated with Na+ channels at the nodes of Ranvier, where it aligns with the forming nodes, Gliomedin is a 551 amino acid protein encoded by the human gene GLDN |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
CRG-L2 CLOM colmedin UNC-112 |
| Also known as: |
Gliomedin Polyclonal Antibody |
| Other name: |
Anti-Gliomedin Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Gliomedin |
| Short name: |
Anti-Gliomedin (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Gliomedin (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
29514 |
| Gene: |
GLDN |
More about : GLDN |
| Long gene name: |
gliomedin |
| Synonyms gene: |
COLM |
| Synonyms gene name: |
collomin |
| Locus: |
15q21, 2 |
| Discovery year: |
2004-05-18 |
| GenBank acession: |
AY358144 |
| Entrez gene record: |
342035 |
| Pubmed identfication: |
16039564 12642876 |
| RefSeq identity: |
NM_181789 |
| Havana BLAST/BLAT: |
OTTHUMG00000131746 |