| Long name: |
ALEXA FLUOR 488 Conjugated, HDAC3/HD3 Polyclonal Antibody |
| Also known as: |
Anti-HDAC3/HD3 PAb ALEXA FLUOR 488 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
488, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
HDAC3/HD3 |
| Specificity: |
This is a highly specific antibody against HDAC3/HD3 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Subcellular location: |
Nucleus |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human HDAC3/HD3 |
| Gene ID Number: |
8841 |
| Swiss Prot: |
O15379 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation, H2B, H3 and H4), Histone deacetylases act via the formation of large multiprotein complexes, Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1, Required to repress transcription of the POU1F1 transcription factor, and some other non-histone substrates, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression, cell cycle progression and developmental events, increases YY1 repression activity, Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
499nm/519nm |
| Synonyms: |
RPD3 HD3 RPD3-2 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the HDAC3/HD3 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
HDAC3/HD3 |
| Short name: |
HDAC3/HD3 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 488 |
| Alternative name: |
ALEXA FLUOR 488, histone deacetylase 3/HD3 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
DNA-templated and biological process this GO :0006476 and protein deacetylation and biological process this GO :0007219 and Notch signaling pathway and biological process this GO :0007346 and regulation of mitotic cell cycle and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0008152 and metabolic process and biological process this GO :0016568 and chromatin modification and biological process this GO :0016575 and histone deacetylation and biological process this GO :0016787 and hydrolase activity and molecular function this GO :0017053 and transcriptional repressor complex and cellular component this GO :0019899 and enzyme binding and molecular function this GO :0030332 and cyclin binding and molecular function this GO :0031490 and chromatin DNA binding and molecular function this GO :0032041 and NAD-dependent histone deacetylase activity (H3-K14 specific) and molecular function this GO :0032922 and circadian regulation of gene expression and biological process this GO :0033558 and protein deacetylase activity and molecular function this GO :0040014 and regulation of multicellular organism growth and biological process this GO :0042826 and histone deacetylase binding and molecular function this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0044255 and cellular lipid metabolic process and biological process this GO :0044281 and small molecule metabolic process and biological process this GO :0045786 and negative regulation of cell cycle and biological process this GO :0045892 and negative regulation of transcription, DNA-templated and biological process this GO :0046329 and negative regulation of JNK cascade and biological process this GO :0046969 and NAD-dependent histone deacetylase activity (H3-K9 specific) and molecular function this GO :0046970 and NAD-dependent histone deacetylase activity (H4-K16 specific) and molecular function this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0051225 and spindle assembly and biological process this GO :0070932 and histone H3 deacetylation and biological process this GO :0070933 and histone H4 deacetylation and biological process this GO :0097372 and NAD-dependent histone deacetylase activity (H3-K18 specific) and molecular function, HD3 and RPD3 and RPD3-2, HDAC3 and IDBG-50725 and ENSG00000171720 and 8841, HDAC3 and IDBG-646121 and ENSBTAG00000017360 and 404125, Hdac3 and IDBG-140814 and ENSMUSG00000024454 and 15183, NAD-dependent histone deacetylase activity (H3-K18 specific), nuclei, this GO :0000118 and histone deacetylase complex and cellular component this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0003677 and DNA binding and molecular function this GO :0003682 and chromatin binding and molecular function this GO :0003714 and transcription corepressor activity and molecular function this GO :0004407 and histone deacetylase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005876 and spindle microtubule and cellular component this GO :0006351 and transcription, this GO :0003677 : DNA binding, this GO :0003677 : DNA binding and also this GO :0003682 : chromatin binding and also this GO :0003714 : transcription corepressor activity and also this GO :0004407 : histone deacetylase activity and also this GO :0005515 : protein binding and also this GO :0008134 : transcription factor binding and also this GO :0016787 : hydrolase activity and also this GO :0019899 : enzyme binding and also this GO :0030332 : cyclin binding and also this GO :0031490 : chromatin DNA binding and also this GO :0032041 : NAD-dependent histone deacetylase activity (H3-K14 specific) and also this GO :0033558 : protein deacetylase activity and also this GO :0042826 : histone deacetylase binding and also this GO :0046969 : NAD-dependent histone deacetylase activity (H3-K9 specific) and also this GO :0046970 : NAD-dependent histone deacetylase activity (H4-K16 specific) and also this GO :0097372 : NAD-dependent histone deacetylase activity (H3-K18 specific), this GO :0003682 : chromatin binding, this GO :0003714 : transcription corepressor activity, this GO :0004407 : histone deacetylase activity, this GO :0005515 : protein binding, this GO :0008134 : transcription factor binding, this GO :0016787 : hydrolase activity, this GO :0019899 : enzyme binding, this GO :0030332 : cyclin binding, this GO :0031490 : chromatin DNA binding, this GO :0032041 : NAD-dependent histone deacetylase activity (H3-K14 specific), this GO :0033558 : protein deacetylase activity, this GO :0042826 : histone deacetylase binding, this GO :0046969 : NAD-dependent histone deacetylase activity (H3-K9 specific), this GO :0046970 : NAD-dependent histone deacetylase activity (H4-K16 specific), this GO :0097372 : NAD-dependent histone deacetylase activity (H3-K18 specific), histone deacetylase 3 |
| Identity: |
4854 |
| Gene: |
HDAC3 |
More about : HDAC3 |
| Long gene name: |
histone deacetylase 3 |
| Locus: |
5q31, 3 |
| Discovery year: |
1999-01-29 |
| GenBank acession: |
AF059650 |
| Entrez gene record: |
8841 |
| Pubmed identfication: |
9501169 9464271 |
| RefSeq identity: |
NM_003883 |
| Classification: |
Histone deacetylases, class I |
| Havana BLAST/BLAT: |
OTTHUMG00000129629 |