PCNA Antibody, Biotin Conjugated

Catalog number:	bs-0754R-Biotin Buy Now
Price:	368 €
Supplier:	Bioss Primary Conjugated Antibodies
Product name:	PCNA Antibody, Biotin Conjugated
Quantity:	0.1ml
Related search:	pcna dna antibodies biotin gene replication damage short

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Long name:	Biotin Conjugated, PCNA Polyclonal Antibody
Category:	Conjugated Primary Antibodies
Conjugation:	Biotinylated
Host Organism:	Rabbit (Oryctolagus cuniculus)
Target Antigen:	PCNA
Specificity:	This is a highly specific antibody against PCNA
Modification:	Unmodified
Modification site:	None
Clonality:	Polyclonal
Clone:	Polyclonal antibody
Concentration:	1ug per 1ul
Immunogen_range:	220-260/261
Subcellular location:	Nucleus
Source:	KLH conjugated synthetic peptide derived from human PCNA
Gene ID number:	5111
Swiss Prot:	P12004
Tested applications:	IHC-P, WB
Recommended dilutions:	IHC-P(1:100-500), WB(1:100-1000)
Crossreactivity:	Mouse, Rat, Human
Crossreactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background:	APEX2 activities, Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, Has to be loaded onto DNA in order to be able to stimulate APEX2, Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways, but not apurinic-apyrimidinic (AP) endonuclease, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion, Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand
Purification method:	This antibody was purified via Protein A
Storage conditions:	50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Properties:	Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene target:	PCNA Conjugated
Short name:	Conjugated, PCNA Antibody
Technique:	antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
Label:	Biotin
Alternative name:	biotinilated coupled, PCNA (Antibody to)
Alternative technique:	antibodies
Identity:	8729
Gene:	PCNA | More about : PCNA
Long gene name:	proliferating cell nuclear antigen
Locus:	20p12, 3
Discovery year:	1990-01-15
GenBank acession:	J04718
Entrez gene record:	5111
Pubmed identfication:	2565339
Havana BLAST/BLAT:	OTTHUMG00000031798

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