| Long name: |
WNK4 Primary Polyclonal Antibody |
| Also known as: |
WNK4 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
WNK4 |
| Specificity: |
This is a highly specific antibody against WNK4 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human WNK4 |
| Gene ID number: |
65266 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Also inhibits the renal K(+)channel, KCNJ1, SLC12A3, WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+)secretion to maintain integrated homeostasis, by phosphorylation which appears to prevent membrane trafficking of SLC12A3, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis, Regulates the activity of the thiazide-sensitive Na-Cl cotransporter |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
PHA2B, PRKWNK 4, PRKWNK4, Protein kinase lysine deficient 4, Protein kinase with no lysine 4, Serine/threonine protein kinase WNK4, WNK lysine deficient protein kinase 4, WNK4_HUMAN, PHA 2B |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
WNK4 |
| Short name: |
WNK4 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
WNK lysine deficient protein kinase 4 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Cell surfaces, WNK4 and IDBG-51675 and ENSG00000126562 and 102724304, WNK4 and IDBG-640438 and ENSBTAG00000019907 and 100849076, Wnk4 and IDBG-211994 and ENSMUSG00000035112 and 69847, this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005923 and tight junction and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006811 and ion transport and biological process this GO :0006821 and chloride transport and biological process this GO :0008104 and protein localization and biological process this GO :0016772 and transferase activity, this GO :0004672 : protein kinase activity, this GO :0004672 : protein kinase activity and also this GO :0004674 : protein serine/threonine kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, this GO :0004674 : protein serine/threonine kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016772 : transferase activity, this GO :0019869 : chloride channel inhibitor activity, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0019869 : chloride channel inhibitor activity, transferring phosphorus-containing groups and molecular function this GO :0019869 and chloride channel inhibitor activity and molecular function this GO :0035556 and intracellular signal transduction and biological process this GO :0050794 and regulation of cellular process and biological process this GO :0050801 and ion homeostasis and biological process this GO :0070294 and renal sodium ion absorption and biological process this GO :0072156 and distal tubule morphogenesis and biological process this GO :0090188 and negative regulation of pancreatic juice secretion and biological process, 65266, WNK lysine deficient protein kinase 4 |
| Identity: |
14544 |
| Gene: |
WNK4 |
More about : WNK4 |
| Long gene name: |
WNK lysine deficient protein kinase 4 |
| Synonyms gene: |
PRKWNK4 |
| Synonyms gene name: |
lysine deficient 4 , protein kinase |
| Locus: |
17q21, 2 |
| Discovery year: |
2001-02-07 |
| GenBank acession: |
AJ309861 |
| Entrez gene record: |
65266 |
| Havana BLAST/BLAT: |
OTTHUMG00000180650 |