| Long name: |
ALEXA FLUOR 488 Conjugated, HCV-NS3 Polyclonal Antibody |
| Also known as: |
Anti-HCV-NS3 PAb ALEXA FLUOR 488 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
488, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
HCV-NS3 |
| Specificity: |
This is a highly specific antibody against HCV-NS3 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
1400-1550/3010 |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human HCV-NS3 |
| Swiss Prot: |
Q9WMX2 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Virus |
| Cross-reactive species details: |
HCV |
| Background of the antigen: |
Also regulates many host cellular functions such as signaling pathways and apoptosis, Also represses cell cycle negative regulating factor CDKN1A, Enhances TRAIL mediated apoptosis, Interacts with, May alter lipid metabolism by interacting with hepatocellular proteins involved in lipid accumulation and storage, May repress the promoter of p53, May suppress the human FOS and HIV-1 LTR activity, May transactivate human MYC, Mediates apoptotic pathways throught association with TNF-type receptors TNFRSF1A and LTBR, Modulates viral translation initiation by interacting with HCV IRES and 40S ribosomal subunit, Plays an important role in virus-mediated cell transformation leading to hepatocellular carcinomas, Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways and by inducing human STAT1 degradation, Rous sarcoma virus LTR, Secreted core protein is able to bind C1QR1 at the T-cell surface, Targets transcription factors involved in the regulation of inflammatory responses and in the immune response: suppresses NK-kappaB activation, although its effect on death receptors-induced apoptosis remains controvertial, and SV40 promoters, and activates AP-1, and activates STAT3 leading to cellular transformation, and promotes virion budding, and sequester CREB3 and SP110 isoform3/Sp110b in the cytoplasm, resulting in down-regulation of T-lymphocytes proliferation, suggesting that it might play a role in immune-mediated liver cell injury, suggesting that it might play a role in mediated apoptosis, thereby interrupting an important check point of normal cell cycle regulation, Core protein packages viral RNA to form a viral nucleocapsid |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
499nm/519nm |
| Synonyms: |
Hepacivirin, NS3P, POLG_HCVBK, Serine protease NS3 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the HCV-NS3 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene: |
2, 3, 4, 5, HCV Core antigens or envelope proteins are used for immunization to obtain diagnostic antibodies, Hepatitis C virus is the cause of , NS genotypes 1, NS4, are small (55&ndash, , , (HCV) NS3, (Hepatocellular carcinoma , 65 , Hepatitis C virus , Liver Cancer , RNA viruses, abbreviated HCC) and , and some cancers such as , enveloped, hepatitis C , in humans, in size), lymphomas , nm , positive-sense , single-stranded |
More about : 2, 3, 4, 5, HCV Core antigens or envelope proteins are used for immunization to obtain diagnostic antibodies, Hepatitis C virus is the cause of , NS genotypes 1, NS4, are small (55&ndash, , , (HCV) NS3, (Hepatocellular carcinoma , 65 , Hepatitis C virus , Liver Cancer , RNA viruses, abbreviated HCC) and , and some cancers such as , enveloped, hepatitis C , in humans, in size), lymphomas , nm , positive-sense , single-stranded |
| Gene target: |
HCV-NS3 |
| Short name: |
HCV-NS3 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 488 |
| Alternative name: |
ALEXA FLUOR 488, Hepatitis C virus-NS3 (Antibody to) |
| Alternative technique: |
antibodies |