| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
HCV-NS3 |
| Specificity: |
This antibody reacts specifically with HCV-NS3 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human HCV-NS3 |
| Swiss Prot: |
Q9WMX2 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Virus |
| Cross Reactive Species details: |
HCV |
| Background information: |
Also regulates many host cellular functions such as signaling pathways and apoptosis, Also represses cell cycle negative regulating factor CDKN1A, Enhances TRAIL mediated apoptosis, Interacts with, May alter lipid metabolism by interacting with hepatocellular proteins involved in lipid accumulation and storage, May repress the promoter of p53, May suppress the human FOS and HIV-1 LTR activity, May transactivate human MYC, Mediates apoptotic pathways throught association with TNF-type receptors TNFRSF1A and LTBR, Modulates viral translation initiation by interacting with HCV IRES and 40S ribosomal subunit, Plays an important role in virus-mediated cell transformation leading to hepatocellular carcinomas, Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways and by inducing human STAT1 degradation, Rous sarcoma virus LTR, Secreted core protein is able to bind C1QR1 at the T-cell surface, Targets transcription factors involved in the regulation of inflammatory responses and in the immune response: suppresses NK-kappaB activation, although its effect on death receptors-induced apoptosis remains controvertial, and SV40 promoters, and activates AP-1, and activates STAT3 leading to cellular transformation, and promotes virion budding, and sequester CREB3 and SP110 isoform3/Sp110b in the cytoplasm, resulting in down-regulation of T-lymphocytes proliferation, suggesting that it might play a role in immune-mediated liver cell injury, suggesting that it might play a role in mediated apoptosis, thereby interrupting an important check point of normal cell cycle regulation, Core protein packages viral RNA to form a viral nucleocapsid |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
Hepacivirin, NS3P, POLG_HCVBK, Serine protease NS3 |
| Also known as: |
HCV-NS3 Polyclonal Antibody |
| Other name: |
Anti-HCV-NS3 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene: |
2, 3, 4, 5, HCV Core antigens or envelope proteins are used for immunization to obtain diagnostic antibodies, Hepatitis C virus is the cause of , NS genotypes 1, NS4, are small (55&ndash, , , (HCV) NS3, (Hepatocellular carcinoma , 65 , Hepatitis C virus , Liver Cancer , RNA viruses, abbreviated HCC) and , and some cancers such as , enveloped, hepatitis C , in humans, in size), lymphomas , nm , positive-sense , single-stranded |
More about : 2, 3, 4, 5, HCV Core antigens or envelope proteins are used for immunization to obtain diagnostic antibodies, Hepatitis C virus is the cause of , NS genotypes 1, NS4, are small (55&ndash, , , (HCV) NS3, (Hepatocellular carcinoma , 65 , Hepatitis C virus , Liver Cancer , RNA viruses, abbreviated HCC) and , and some cancers such as , enveloped, hepatitis C , in humans, in size), lymphomas , nm , positive-sense , single-stranded |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
HCV-NS3 |
| Short name: |
Anti-HCV-NS3 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Hepatitis C virus-NS3 (polyclonal) |
| Alternative technique: |
polyclonals |