| Long name: |
ALEXA FLUOR 647 Conjugated, TrkB Polyclonal Antibody |
| Also known as: |
Anti-TrkB PAb ALEXA FLUOR 647 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
647, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
TrkB |
| Specificity: |
This is a highly specific antibody against TrkB |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
370-429/822 |
| Subcellular location: |
Extracellular |
| Source: |
KLH conjugated synthetic peptide derived from rat TrkB |
| Gene ID Number: |
4915 |
| Swiss Prot: |
Q16620 |
| Tested applications: |
IF(IHC-P), FCM |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), FCM(1:20-100) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2, FRS2, FRS2, Hence, May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia, PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival, Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4, Recruits, SH2B1, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades, Thereby, Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity, Through SHC1, Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival, Upon ligand-binding, and synapse formation and plasticity, autophosphorylation and activation, differentiation, it is able to suppress anoikis, migration, phosphorylates and/or activates several downstream effectors including SHC1, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation, proliferation, the apoptosis resulting from loss of cell-matrix interactions, undergoes homodimerization, Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
650nm/665nm |
| Synonyms: |
TRKB |
| Properties: |
ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the TrkB Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 647, Alexa Fluor |
| Gene target: |
TrkB |
| Short name: |
TrkB Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 647 |
| Alternative name: |
ALEXA FLUOR 647, TrkB (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
8032 |
| Gene: |
NTRK2 |
More about : NTRK2 |
| Long gene name: |
neurotrophic receptor tyrosine kinase 2 |
| Synonyms gene name: |
neurotrophic tyrosine kinase, receptor, type 2 |
| Locus: |
9q21, 33 |
| Discovery year: |
1991-07-18 |
| GenBank acession: |
AF410902 |
| Entrez gene record: |
4915 |
| Pubmed identfication: |
7789988 |
| Classification: |
I-set domain containing Receptor Tyrosine Kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000020120 |