| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
ERCC2 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, WB |
| Recommended dilutions: |
Western blot: 1:1000 |
| Notes: |
Titration of the ERCC2 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This ERCC2 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P18074 |
| Purity: |
Antigen affinity |
| Description: |
As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, Involved in nucleotide excision repair (NER) of DNA by opening DNA around the damage, Involved in the regulation of vitamin-D receptor activity, Might have a role in aging process and could play a causative role in the generation of skin cancers, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase (CAK) complex, component of the core- TFIIH basal transcription factor, composed of CDK7, cyclin H and MAT1, to the core-TFIIH complex, ATP-dependent 5'-3' DNA helicase |
| Immunogen: |
This ERCC2 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 687-722 amino acids from the C-terminal region of human ERCC2 |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the ERCC2 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
ERCC2 |
| Short name: |
ERCC2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
complementation family 2 (Antibody to), excision repair cross-complementing rodent repair deficiency |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
4 sulfur cluster binding, 4 sulfur cluster binding, 4 sulfur cluster binding and molecular function this GO :0060218 and hematopoietic stem cell differentiation and biological process this GO :0071817 and MMXD complex and cellular component this GO :1901990 and regulation of mitotic cell cycle phase transition and biological process, COFS2 and EM9 and TFIIH and TTD and XPD, DNA damage removal and biological process this GO :0001666 and response to hypoxia and biological process this GO :0001701 and in utero embryonic development and biological process this GO :0003676 and nucleic acid binding and molecular function this GO :0003677 and DNA binding and molecular function this GO :0004003 and ATP-dependent DNA helicase activity and molecular function this GO :0004672 and protein kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005675 and holo TFIIH complex and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005819 and spindle and cellular component this GO :0006139 and nucleobase-containing compound metabolic process and biological process this GO :0006200 and ATP catabolic process and biological process this GO :0006281 and DNA repair and biological process this GO :0006283 and transcription-coupled nucleotide-excision repair and biological process this GO :0006289 and nucleotide-excision repair and biological process this GO :0006360 and transcription from RNA polymerase I promoter and biological process this GO :0006361 and transcription initiation from RNA polymerase I promoter and biological process this GO :0006362 and transcription elongation from RNA polymerase I promoter and biological process this GO :0006363 and termination of RNA polymerase I transcription and biological process this GO :0006366 and transcription from RNA polymerase II promoter and biological process this GO :0006367 and transcription initiation from RNA polymerase II promoter and biological process this GO :0006368 and transcription elongation from RNA polymerase II promoter and biological process this GO :0006370 and 7-methylguanosine mRNA capping and biological process this GO :0006468 and protein phosphorylation and biological process this GO :0006915 and apoptotic process and biological process this GO :0006979 and response to oxidative stress and biological process this GO :0007059 and chromosome segregation and biological process this GO :0007568 and aging and biological process this GO :0008022 and protein C-terminus binding and molecular function this GO :0008026 and ATP-dependent helicase activity and molecular function this GO :0008094 and DNA-dependent ATPase activity and molecular function this GO :0008283 and cell proliferation and biological process this GO :0008353 and RNA polymerase II carboxy-terminal domain kinase activity and molecular function this GO :0009411 and response to UV and biological process this GO :0009650 and UV protection and biological process this GO :0009791 and post-embryonic development and biological process this GO :0010467 and gene expression and biological process this GO :0016032 and viral process and biological process this GO :0016818 and hydrolase activity, DNA incision and biological process this GO :0035264 and multicellular organism growth and biological process this GO :0035315 and hair cell differentiation and biological process this GO :0040016 and embryonic cleavage and biological process this GO :0043139 and 5'-3' DNA helicase activity and molecular function this GO :0043249 and erythrocyte maturation and biological process this GO :0043388 and positive regulation of DNA binding and biological process this GO :0043588 and skin development and biological process this GO :0044281 and small molecule metabolic process and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046872 and metal ion binding and molecular function this GO :0047485 and protein N-terminus binding and molecular function this GO :0048820 and hair follicle maturation and biological process this GO :0050434 and positive regulation of viral transcription and biological process this GO :0051539 and 4 iron, ERCC2 and IDBG-57385 and ENSG00000104884 and 2068, ERCC2 and IDBG-639452 and ENSBTAG00000002072 and 100125238, Ercc2 and IDBG-150400 and ENSMUSG00000030400 and 13871, acting on acid anhydrides, acting on acid anhydrides, acting on acid anhydrides, complementation group 2, hydrolase activity, in phosphorus-containing anhydrides, in phosphorus-containing anhydrides and also this GO :0043139 : 5'-3' DNA helicase activity and also this GO :0046872 : metal ion binding and also this GO :0047485 : protein N-terminus binding and also this GO :0051539 : 4 iron, in phosphorus-containing anhydrides and molecular function this GO :0019907 and cyclin-dependent protein kinase activating kinase holoenzyme complex and cellular component this GO :0021510 and spinal cord development and biological process this GO :0022405 and hair cycle process and biological process this GO :0030198 and extracellular matrix organization and biological process this GO :0030282 and bone mineralization and biological process this GO :0032289 and central nervous system myelin formation and biological process this GO :0032508 and DNA duplex unwinding and biological process this GO :0033683 and nucleotide-excision repair, nuclei, this GO :0000439 and core TFIIH complex and cellular component this GO :0000718 and nucleotide-excision repair, this GO :0003676 : nucleic acid binding, this GO :0003676 : nucleic acid binding and also this GO :0003677 : DNA binding and also this GO :0004003 : ATP-dependent DNA helicase activity and also this GO :0004672 : protein kinase activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0008022 : protein C-terminus binding and also this GO :0008026 : ATP-dependent helicase activity and also this GO :0008094 : DNA-dependent ATPase activity and also this GO :0008353 : RNA polymerase II carboxy-terminal domain kinase activity and also this GO :0016818 : hydrolase activity, this GO :0003677 : DNA binding, this GO :0004003 : ATP-dependent DNA helicase activity, this GO :0004672 : protein kinase activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0008022 : protein C-terminus binding, this GO :0008026 : ATP-dependent helicase activity, this GO :0008094 : DNA-dependent ATPase activity, this GO :0008353 : RNA polymerase II carboxy-terminal domain kinase activity, this GO :0016818 : hydrolase activity, this GO :0043139 : 5'-3' DNA helicase activity, this GO :0046872 : metal ion binding, this GO :0047485 : protein N-terminus binding, this GO :0051539 : 4 iron, excision repair cross-complementing rodent repair deficiency |
| Identity: |
3434 |
| Gene: |
ERCC2 |
More about : ERCC2 |
| Long gene name: |
ERCC excision repair 2, TFIIH core complex helicase subunit |
| Synonyms gene: |
XPD |
| Synonyms gene name: |
complementation group 2 excision repair cross-complementation group 2 , xeroderma pigmentosum complementary group D excision repair cross-complementing rodent repair deficiency |
| Synonyms: |
MAG EM9 MGC102762 MGC126218 MGC126219 TFIIH |
| Synonyms name: |
complementation group 2 protein TFIIH basal transcription factor complex helicase XPB subunit , excision repair cross-complementing rodent repair deficiency |
| Locus: |
19q13, 32 |
| Discovery year: |
2001-06-22 |
| Entrez gene record: |
2068 |
| Pubmed identfication: |
8413672 2184031 |
| RefSeq identity: |
NM_000400 |
| Classification: |
Xeroderma pigmentosum complementation groups General transcription factors ERCC excision repair associated DNA helicases |
| Havana BLAST/BLAT: |
OTTHUMG00000048190 |
| Locus Specific Databases: |
The Globin Gene Server LRG_461 |