| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
PDX1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Rat , we cannot guarantee that no other cross reactivity can occur, Mouse (Mus musculus) |
| Tested applications: |
ELISA, WB |
| Recommended dilutions: |
Western blot: 1:1000 |
| Notes: |
Titration of the PDX1 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This PDX1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P52945 |
| Purity: |
Antigen affinity |
| Description: |
As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer, At adult stage, Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3', During development, Particularly involved in glucose-dependent regulation of insulin gene transcription, branching and subsequent differentiation, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription, permitting its proliferation, required for maintaining the hormone-producing phenotype of the beta-cell, somatostatin, specifies the early pancreatic epithelium, the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element, Activates insulin |
| Immunogen: |
This PDX1 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 21-55 amino acids from the N-terminal region of human PDX1 |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the PDX1 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
PDX1 |
| Short name: |
PDX1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
PDX1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
21350 |
| Gene: |
PDHX |
More about : PDHX |
| Long gene name: |
pyruvate dehydrogenase complex component X |
| Synonyms: |
E3BP proX PDX1 OPDX DLDBP |
| Locus: |
11p13 |
| Discovery year: |
2003-06-24 |
| GenBank acession: |
U82328 |
| Entrez gene record: |
8050 |
| Pubmed identfication: |
9467010 12372595 |
| RefSeq identity: |
NM_003477 |
| Havana BLAST/BLAT: |
OTTHUMG00000166491 |