| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
OPA1 (form S1) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, WB |
| Recommended dilutions: |
Western blot: 1:1000 |
| Notes: |
Titration of the OPA1 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This OPA1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
O60313 |
| Purity: |
Antigen affinity |
| Description: |
May form a diffusion barrier for proteins stored in mitochondrial cristae, Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space, Dynamin-related GTPase required for mitochondrial fusion and regulation of apoptosis |
| Immunogen: |
form S1, This OPA1 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 895-929 amino acids from the C-terminal region of human OPA1 |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the OPA1 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
OPA1 (form S1) |
| Short name: |
OPA1 Antibody (form S1) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
optic atrophy 1 (autosomal dominant) (Antibody to) (form S1) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
GTP binding, OPA1 and IDBG-634327 and ENSBTAG00000019514 and 524142, OPA1 and IDBG-70072 and ENSG00000198836 and 4976, Opa1 and IDBG-151468 and ENSMUSG00000038084 and 74143, Plasma membranes, largeG and MGM1 and NPG and NTG, this GO :0000266 and mitochondrial fission and biological process this GO :0000287 and magnesium ion binding and molecular function this GO :0001843 and neural tube closure and biological process this GO :0003924 and GTPase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005525 and GTP binding and molecular function this GO :0005739 and mitochondrion and cellular component this GO :0005741 and mitochondrial outer membrane and cellular component this GO :0005743 and mitochondrial inner membrane and cellular component this GO :0005758 and mitochondrial intermembrane space and cellular component this GO :0006184 and GTP catabolic process and biological process this GO :0006915 and apoptotic process and biological process this GO :0007005 and mitochondrion organization and biological process this GO :0007007 and inner mitochondrial membrane organization and biological process this GO :0007601 and visual perception and biological process this GO :0008053 and mitochondrial fusion and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0019896 and axon transport of mitochondrion and biological process this GO :0030061 and mitochondrial crista and cellular component this GO :0030425 and dendrite and cellular component this GO :0090201 and negative regulation of release of cytochrome c from mitochondria and biological process this GO :0090398 and cellular senescence and biological process this GO :2001243 and negative regulation of intrinsic apoptotic signaling pathway and biological process, this GO :0000287 : magnesium ion binding, this GO :0000287 : magnesium ion binding and also this GO :0003924 : GTPase activity and also this GO :0005515 : protein binding and also this GO :0005525 : GTP binding, this GO :0003924 : GTPase activity, this GO :0005515 : protein binding, this GO :0005525 : GTP binding, optic atrophy 1 (autosomal dominant) |
| Identity: |
8140 |
| Gene: |
OPA1 |
More about : OPA1 |
| Long gene name: |
OPA1, mitochondrial dynamin like GTPase |
| Synonyms gene name: |
optic atrophy 1 (autosomal dominant) |
| Synonyms: |
NTG KIAA0567 FLJ12460 NPG MGM1 |
| Synonyms name: |
mitochondrial , mitochondrial dynamin-like GTPase dynamin-like guanosine triphosphatase Dynamin-like 120 kDa protein |
| Locus: |
3q29 |
| Discovery year: |
1987-09-11 |
| GenBank acession: |
AB011139 |
| Entrez gene record: |
4976 |
| Pubmed identfication: |
9490303 |
| RefSeq identity: |
NM_130837 |
| Havana BLAST/BLAT: |
OTTHUMG00000149897 |
| Locus Specific Databases: |
Mutations of the Optic Atrophy 1 Gene LRG_337 |