| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
OPA1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
1-0, 5-1ug/ml, 5ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Optimal dilution of the OPA1 antibody should be determined by the researcher |
| Intented use: |
This OPA1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
O60313 |
| Purity: |
Antigen affinity |
| Description: |
It is a component of the mitochondrial network, It is mapped to 3q29, Multiple transcript variants encoding different isoforms have been found for this gene, Mutations in this gene have been associated with optic atrophy type 1, This gene product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases, This protein regulates mitochondrial fusion and cristae structure in the inner mitochondrial membrane (IMM) and contributes to ATP synthesis and apoptosis, leading in many cases to legal blindness, mitochondrial is a protein that in humans is encoded by the OPA1 gene, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, Dynamin-like 120 kDa protein |
| Immunogen: |
Amino acids EDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEA of human OPA1 were used as the immunogen for the OPA1 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the OPA1 antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term |
| Localization: |
membrane, Cytoplasmic |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
OPA1 |
| Short name: |
OPA1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
optic atrophy 1 (autosomal dominant) (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
GTP binding, OPA1 and IDBG-634327 and ENSBTAG00000019514 and 524142, OPA1 and IDBG-70072 and ENSG00000198836 and 4976, Opa1 and IDBG-151468 and ENSMUSG00000038084 and 74143, Plasma membranes, largeG and MGM1 and NPG and NTG, this GO :0000266 and mitochondrial fission and biological process this GO :0000287 and magnesium ion binding and molecular function this GO :0001843 and neural tube closure and biological process this GO :0003924 and GTPase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005525 and GTP binding and molecular function this GO :0005739 and mitochondrion and cellular component this GO :0005741 and mitochondrial outer membrane and cellular component this GO :0005743 and mitochondrial inner membrane and cellular component this GO :0005758 and mitochondrial intermembrane space and cellular component this GO :0006184 and GTP catabolic process and biological process this GO :0006915 and apoptotic process and biological process this GO :0007005 and mitochondrion organization and biological process this GO :0007007 and inner mitochondrial membrane organization and biological process this GO :0007601 and visual perception and biological process this GO :0008053 and mitochondrial fusion and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0019896 and axon transport of mitochondrion and biological process this GO :0030061 and mitochondrial crista and cellular component this GO :0030425 and dendrite and cellular component this GO :0090201 and negative regulation of release of cytochrome c from mitochondria and biological process this GO :0090398 and cellular senescence and biological process this GO :2001243 and negative regulation of intrinsic apoptotic signaling pathway and biological process, this GO :0000287 : magnesium ion binding, this GO :0000287 : magnesium ion binding and also this GO :0003924 : GTPase activity and also this GO :0005515 : protein binding and also this GO :0005525 : GTP binding, this GO :0003924 : GTPase activity, this GO :0005515 : protein binding, this GO :0005525 : GTP binding, optic atrophy 1 (autosomal dominant) |
| Identity: |
8140 |
| Gene: |
OPA1 |
More about : OPA1 |
| Long gene name: |
OPA1, mitochondrial dynamin like GTPase |
| Synonyms gene name: |
optic atrophy 1 (autosomal dominant) |
| Synonyms: |
NTG KIAA0567 FLJ12460 NPG MGM1 |
| Synonyms name: |
mitochondrial , mitochondrial dynamin-like GTPase dynamin-like guanosine triphosphatase Dynamin-like 120 kDa protein |
| Locus: |
3q29 |
| Discovery year: |
1987-09-11 |
| GenBank acession: |
AB011139 |
| Entrez gene record: |
4976 |
| Pubmed identfication: |
9490303 |
| RefSeq identity: |
NM_130837 |
| Havana BLAST/BLAT: |
OTTHUMG00000149897 |
| Locus Specific Databases: |
Mutations of the Optic Atrophy 1 Gene LRG_337 |