| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
JNK2 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, IHC, WB |
| Recommended dilutions: |
IHC (Paraffin): 1:50-1:100, Western blot: 1:1000 |
| Notes: |
Titration of the JNK2 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This JNK2 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P45984 |
| Purity: |
Antigen affinity |
| Description: |
However, In T-cells, It is inhibited by dual specificity phosphatases, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells, JNK2 is activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases, JNK2 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to c-Jun, JUNB is not a substrate for JNK2 alpha-2, MAP2K4 and MAP2K7, MAPK8IP1/JIP-1, MAPK8IP2/JIP-2 and MAPK8IP3/JIP-3/JSAP1, The protein has been shown to bind to at least three scaffolding proteins, These proteins also bind other components of the JNK signaling pathway, and JUND binds only weakly to it, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity, such as DUSP1, there is no correlation between binding and phosphorylation, whereas beta-1 and beta-2 bind to ATF2, which is achieved at about the same efficiency by all isoforms, JNK2 responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors |
| Immunogen: |
A portion of amino acids 349-379 from the human protein was used as the immunogen for this JNK2 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the JNK2 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
JNK2 |
| Short name: |
JNK2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
JNK2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
6886 |
| Gene: |
MAPK9 |
More about : MAPK9 |
| Long gene name: |
mitogen-activated protein kinase 9 |
| Synonyms gene: |
PRKM9 |
| Synonyms: |
JNK2 p54a SAPK |
| Synonyms name: |
Jun kinase |
| Locus: |
5q35, 3 |
| Discovery year: |
1998-04-28 |
| GenBank acession: |
U09759 |
| Entrez gene record: |
5601 |
| Pubmed identfication: |
8001819 |
| Classification: |
Mitogen-activated protein kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000130934 |