| Category: |
Antibody |
| Concentration: |
09% sodium azide, 4 with 0, In 1X PBS pH 7 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
JNK2 (MAPK9) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, IHC, WB |
| Recommended dilutions: |
IHC (Paraffin): 1:50-1:100, Western blot: 1:1000 |
| Notes: |
Titration of the JNK2 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This JNK2 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P45984 |
| Purity: |
Antigen affinity |
| Description: |
However, In T-cells, It is inhibited by dual specificity phosphatases, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells, JNK2 is activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases, JNK2 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to c-Jun, JUNB is not a substrate for JNK2 alpha-2, MAP2K4 and MAP2K7, MAPK8IP1/JIP-1, MAPK8IP2/JIP-2 and MAPK8IP3/JIP-3/JSAP1, The protein has been shown to bind to at least three scaffolding proteins, These proteins also bind other components of the JNK signaling pathway, and JUND binds only weakly to it, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity, such as DUSP1, there is no correlation between binding and phosphorylation, whereas beta-1 and beta-2 bind to ATF2, which is achieved at about the same efficiency by all isoforms, JNK2 responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors |
| Immunogen: |
A portion of amino acids 349-379 from the human protein was used as the immunogen for this JNK2 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the JNK2 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
JNK2 (MAPK9) |
| Short name: |
JNK2 Antibody (MAPK9) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
JNK2 (Antibody to) (mitogen-activated protein kinase 9) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
DNA-templated and biological process this GO :0046328 and regulation of JNK cascade and biological process this GO :0046686 and response to cadmium ion and biological process this GO :0051090 and regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0051403 and stress-activated MAPK cascade and biological process this GO :0051770 and positive regulation of nitric-oxide synthase biosynthetic process and biological process this GO :0071222 and cellular response to lipopolysaccharide and biological process this GO :0071347 and cellular response to interleukin-1 and biological process this GO :0071356 and cellular response to tumor necrosis factor and biological process this GO :0071363 and cellular response to growth factor stimulus and biological process this GO :2001235 and positive regulation of apoptotic signaling pathway and biological process, JNK-55 and JNK2 and JNK2A and JNK2ALPHA and JNK2B and JNK2BETA and p54a and p54aSAPK and PRKM9 and SAPK and SAPK1a, MAPK9 and IDBG-62183 and ENSG00000050748 and 5601, MAPK9 and IDBG-640895 and ENSBTAG00000004709 and 534125, Mapk9 and IDBG-167617 and ENSMUSG00000020366 and 26420, alcohol group as acceptor, alcohol group as acceptor and also this GO :0031435 : mitogen-activated protein kinase kinase kinase binding, alcohol group as acceptor and molecular function this GO :0031175 and neuron projection development and biological process this GO :0031394 and positive regulation of prostaglandin biosynthetic process and biological process this GO :0031396 and regulation of protein ubiquitination and biological process this GO :0031435 and mitogen-activated protein kinase kinase kinase binding and molecular function this GO :0032308 and positive regulation of prostaglandin secretion and biological process this GO :0032722 and positive regulation of chemokine production and biological process this GO :0034134 and toll-like receptor 2 signaling pathway and biological process this GO :0034138 and toll-like receptor 3 signaling pathway and biological process this GO :0034142 and toll-like receptor 4 signaling pathway and biological process this GO :0034146 and toll-like receptor 5 signaling pathway and biological process this GO :0034162 and toll-like receptor 9 signaling pathway and biological process this GO :0034166 and toll-like receptor 10 signaling pathway and biological process this GO :0034644 and cellular response to UV and biological process this GO :0035666 and TRIF-dependent toll-like receptor signaling pathway and biological process this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0038123 and toll-like receptor TLR1:TLR2 signaling pathway and biological process this GO :0038124 and toll-like receptor TLR6:TLR2 signaling pathway and biological process this GO :0042493 and response to drug and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043280 and positive regulation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0045087 and innate immune response and biological process this GO :0045429 and positive regulation of nitric oxide biosynthetic process and biological process this GO :0045893 and positive regulation of transcription, nuclei, this GO :0000165 and MAPK cascade and biological process this GO :0001836 and release of cytochrome c from mitochondria and biological process this GO :0001934 and positive regulation of protein phosphorylation and biological process this GO :0002224 and toll-like receptor signaling pathway and biological process this GO :0002755 and MyD88-dependent toll-like receptor signaling pathway and biological process this GO :0002756 and MyD88-independent toll-like receptor signaling pathway and biological process this GO :0003824 and catalytic activity and molecular function this GO :0004672 and protein kinase activity and molecular function this GO :0004705 and JUN kinase activity and molecular function this GO :0004707 and MAP kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005829 and cytosol and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006626 and protein targeting to mitochondrion and biological process this GO :0006919 and activation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0006950 and response to stress and biological process this GO :0007254 and JNK cascade and biological process this GO :0007258 and JUN phosphorylation and biological process this GO :0007417 and central nervous system development and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0008656 and cysteine-type endopeptidase activator activity involved in apoptotic process and molecular function this GO :0009103 and lipopolysaccharide biosynthetic process and biological process this GO :0009612 and response to mechanical stimulus and biological process this GO :0009636 and response to toxic substance and biological process this GO :0010033 and response to organic substance and biological process this GO :0010628 and positive regulation of gene expression and biological process this GO :0010744 and positive regulation of macrophage derived foam cell differentiation and biological process this GO :0010770 and positive regulation of cell morphogenesis involved in differentiation and biological process this GO :0014075 and response to amine and biological process this GO :0016020 and membrane and cellular component this GO :0016301 and kinase activity and molecular function this GO :0016310 and phosphorylation and biological process this GO :0016772 and transferase activity, this GO :0003824 : catalytic activity, this GO :0003824 : catalytic activity and also this GO :0004672 : protein kinase activity and also this GO :0004705 : JUN kinase activity and also this GO :0004707 : MAP kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0008134 : transcription factor binding and also this GO :0008656 : cysteine-type endopeptidase activator activity involved in apoptotic process and also this GO :0016301 : kinase activity and also this GO :0016772 : transferase activity, this GO :0004672 : protein kinase activity, this GO :0004705 : JUN kinase activity, this GO :0004707 : MAP kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0008134 : transcription factor binding, this GO :0008656 : cysteine-type endopeptidase activator activity involved in apoptotic process, this GO :0016301 : kinase activity, this GO :0016772 : transferase activity, this GO :0016773 : phosphotransferase activity, this GO :0031435 : mitogen-activated protein kinase kinase kinase binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0016773 : phosphotransferase activity, transferring phosphorus-containing groups and molecular function this GO :0016773 and phosphotransferase activity, mitogen-activated protein kinase 9 |
| Identity: |
6886 |
| Gene: |
MAPK9 |
More about : MAPK9 |
| Long gene name: |
mitogen-activated protein kinase 9 |
| Synonyms gene: |
PRKM9 |
| Synonyms: |
JNK2 p54a SAPK |
| Synonyms name: |
Jun kinase |
| Locus: |
5q35, 3 |
| Discovery year: |
1998-04-28 |
| GenBank acession: |
U09759 |
| Entrez gene record: |
5601 |
| Pubmed identfication: |
8001819 |
| Classification: |
Mitogen-activated protein kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000130934 |