| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
PARK8 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus) , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, IF, WB |
| Recommended dilutions: |
Immunofluorescence: 1:10-1:50, Western blot: 1:1000 |
| Notes: |
Titration of the PARK8 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This PARK8 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q5S007 |
| Purity: |
Antigen affinity |
| Description: |
6 disease-segregating mutations (5 missense and 1 putative splice site mutation), About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease, By high-resolution recombination mapping and candidate gene sequencing in 46 families, It may be central to the pathogenesis of several major neurodegenerative disorders associated with parkinsonism, LRRK2/PARK8, PARK8 belongs to the ROCO protein family and includes a protein kinase domain of the MAPKKK class and several other major functional domains, The mutation is the most common cause of Parkinson's disease identified to date, a genetic mutation, was recently found linked to about 5 percent of inherited cases of Parkinson's disease, Parkinson is the second most common neurodegenerative disease after Alzheimers |
| Immunogen: |
A portion of amino acids 930-961 from the human protein was used as the immunogen for this PARK8 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the PARK8 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
PARK8 |
| Short name: |
PARK8 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
PARK8 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
18618 |
| Gene: |
LRRK2 |
More about : LRRK2 |
| Long gene name: |
leucine rich repeat kinase 2 |
| Synonyms gene: |
PARK8 |
| Synonyms gene name: |
Parkinson disease (autosomal dominant) 8 |
| Synonyms: |
ROCO2 DKFZp434H2111 FLJ45829 RIPK7 |
| Locus: |
12q12 |
| Discovery year: |
2004-10-22 |
| GenBank acession: |
AK026776 |
| Entrez gene record: |
120892 |
| Pubmed identfication: |
15541308 |
| RefSeq identity: |
XM_058513 |
| Classification: |
Parkinson disease associated genes |
| Havana BLAST/BLAT: |
OTTHUMG00000059742 |
| Locus Specific Databases: |
Parkinson', s disease Mutation Database |