| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
PARK8 (LRRK2) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus) , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, IHC, WB |
| Recommended dilutions: |
IHC (Paraffin): 1:10-1:50, Western blot: 1:1000 |
| Notes: |
Titration of the LRRK2 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This LRRK2 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q5S007 |
| Purity: |
Antigen affinity |
| Description: |
6 disease-segregating mutations (5 missense and 1 putative splice site mutation), About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease, By high-resolution recombination mapping and candidate gene sequencing in 46 families, It may be central to the pathogenesis of several major neurodegenerative disorders associated with parkinsonism, LRRK2, LRRK2 belongs to the ROCO protein family and includes a protein kinase domain of the MAPKKK class and several other major functional domains, The mutation is the most common cause of Parkinson's disease identified to date, a genetic mutation, was recently found linked to about 5 percent of inherited cases of Parkinson's disease, Parkinson is the second most common neurodegenerative disease after Alzheimers |
| Immunogen: |
A portion of amino acids 878-909 from the human protein was used as the immunogen for this LRRK2 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the LRRK2 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
PARK8 (LRRK2) |
| Short name: |
PARK8 Antibody (LRRK2) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
PARK8 (Antibody to) (leucine-rich repeat kinase 2) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Extracellular, LRRK2 and IDBG-27257 and ENSG00000188906 and 120892, LRRK2 and IDBG-633456 and ENSBTAG00000016260 and 535652, Lrrk2 and IDBG-175625 and ENSMUSG00000036273 and 66725, glutamatergic and biological process this GO :0060079 and regulation of excitatory postsynaptic membrane potential and biological process this GO :0060159 and regulation of dopamine receptor signaling pathway and biological process this GO :0060161 and positive regulation of dopamine receptor signaling pathway and biological process this GO :0061001 and regulation of dendritic spine morphogenesis and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0070997 and neuron death and biological process this GO :0071407 and cellular response to organic cyclic compound and biological process this GO :1901214 and regulation of neuron death and biological process this GO :1902692 and regulation of neuroblast proliferation and biological process this GO :1902803 and regulation of synaptic vesicle transport and biological process this GO :1902823 and negative regulation of late endosome to lysosome transport and biological process this GO :1903125 and negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation and biological process this GO :2000172 and regulation of branching morphogenesis of a nerve and biological process this GO :2000300 and regulation of synaptic vesicle exocytosis and biological process, this GO :0000149 and SNARE binding and molecular function this GO :0000165 and MAPK cascade and biological process this GO :0000186 and activation of MAPKK activity and biological process this GO :0000187 and activation of MAPK activity and biological process this GO :0001933 and negative regulation of protein phosphorylation and biological process this GO :0001934 and positive regulation of protein phosphorylation and biological process this GO :0001948 and glycoprotein binding and molecular function this GO :0003779 and actin binding and molecular function this GO :0003924 and GTPase activity and molecular function this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004708 and MAP kinase kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0004857 and enzyme inhibitor activity and molecular function this GO :0005096 and GTPase activator activity and molecular function this GO :0005488 and binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005525 and GTP binding and molecular function this GO :0005615 and extracellular space and cellular component this GO :0005622 and intracellular and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005741 and mitochondrial outer membrane and cellular component this GO :0005743 and mitochondrial inner membrane and cellular component this GO :0005759 and mitochondrial matrix and cellular component this GO :0005764 and lysosome and cellular component this GO :0005768 and endosome and cellular component this GO :0005783 and endoplasmic reticulum and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0005802 and trans- this GO lgi network and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006184 and GTP catabolic process and biological process this GO :0006468 and protein phosphorylation and biological process this GO :0006914 and autophagy and biological process this GO :0006979 and response to oxidative stress and biological process this GO :0007264 and small GTPase mediated signal transduction and biological process this GO :0007528 and neuromuscular junction development and biological process this GO :0008021 and synaptic vesicle and cellular component this GO :0008340 and determination of adult lifespan and biological process this GO :0010508 and positive regulation of autophagy and biological process this GO :0010738 and regulation of protein kinase A signaling and biological process this GO :0014041 and regulation of neuron maturation and biological process this GO :0015031 and protein transport and biological process this GO :0015631 and tubulin binding and molecular function this GO :0016020 and membrane and cellular component this GO :0016234 and inclusion body and cellular component this GO :0016301 and kinase activity and molecular function this GO :0016772 and transferase activity, this GO :0000149 : SNARE binding, this GO :0000149 : SNARE binding and also this GO :0001948 : glycoprotein binding and also this GO :0003779 : actin binding and also this GO :0003924 : GTPase activity and also this GO :0004672 : protein kinase activity and also this GO :0004674 : protein serine/threonine kinase activity and also this GO :0004708 : MAP kinase kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0004857 : enzyme inhibitor activity and also this GO :0005096 : GTPase activator activity and also this GO :0005488 : binding and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0005525 : GTP binding and also this GO :0015631 : tubulin binding and also this GO :0016301 : kinase activity and also this GO :0016772 : transferase activity, this GO :0001948 : glycoprotein binding, this GO :0003779 : actin binding, this GO :0003924 : GTPase activity, this GO :0004672 : protein kinase activity, this GO :0004674 : protein serine/threonine kinase activity, this GO :0004708 : MAP kinase kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0004857 : enzyme inhibitor activity, this GO :0005096 : GTPase activator activity, this GO :0005488 : binding, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0005525 : GTP binding, this GO :0015631 : tubulin binding, this GO :0016301 : kinase activity, this GO :0016772 : transferase activity, this GO :0017048 : Rho GTPase binding, this GO :0017075 : syntaxin-1 binding, this GO :0030276 : clathrin binding, this GO :0034211 : GTP-dependent protein kinase activity, this GO :0042802 : identical protein binding, this GO :0042803 : protein homodimerization activity, this GO :0044325 : ion channel binding, this GO :0051018 : protein kinase A binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0017048 : Rho GTPase binding and also this GO :0017075 : syntaxin-1 binding and also this GO :0030276 : clathrin binding and also this GO :0034211 : GTP-dependent protein kinase activity and also this GO :0042802 : identical protein binding and also this GO :0042803 : protein homodimerization activity and also this GO :0044325 : ion channel binding and also this GO :0051018 : protein kinase A binding, transferring phosphorus-containing groups and molecular function this GO :0017048 and Rho GTPase binding and molecular function this GO :0017075 and syntaxin-1 binding and molecular function this GO :0018105 and peptidyl-serine phosphorylation and biological process this GO :0018107 and peptidyl-threonine phosphorylation and biological process this GO :0021772 and olfactory bulb development and biological process this GO :0022028 and tangential migration from the subventricular zone to the olfactory bulb and biological process this GO :0030276 and clathrin binding and molecular function this GO :0030424 and axon and cellular component this GO :0030425 and dendrite and cellular component this GO :0031398 and positive regulation of protein ubiquitination and biological process this GO :0031410 and cytoplasmic vesicle and cellular component this GO :0031966 and mitochondrial membrane and cellular component this GO :0032091 and negative regulation of protein binding and biological process this GO :0032436 and positive regulation of proteasomal ubiquitin-dependent protein catabolic process and biological process this GO :0032473 and external side of mitochondrial outer membrane and cellular component this GO :0032839 and dendrite cytoplasm and cellular component this GO :0034211 and GTP-dependent protein kinase activity and molecular function this GO :0034260 and negative regulation of GTPase activity and biological process this GO :0034613 and cellular protein localization and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0035564 and regulation of kidney size and biological process this GO :0035640 and exploration behavior and biological process this GO :0035641 and locomotory exploration behavior and biological process this GO :0040012 and regulation of locomotion and biological process this GO :0042391 and regulation of membrane potential and biological process this GO :0042802 and identical protein binding and molecular function this GO :0042803 and protein homodimerization activity and molecular function this GO :0043005 and neuron projection and cellular component this GO :0043025 and neuronal cell body and cellular component this GO :0043068 and positive regulation of programmed cell death and biological process this GO :0043204 and perikaryon and cellular component this GO :0043231 and intracellular membrane-bounded organelle and cellular component this GO :0043547 and positive regulation of GTPase activity and biological process this GO :0044325 and ion channel binding and molecular function this GO :0045087 and innate immune response and biological process this GO :0045121 and membrane raft and cellular component this GO :0045202 and synapse and cellular component this GO :0046777 and protein autophosphorylation and biological process this GO :0048312 and intracellular distribution of mitochondria and biological process this GO :0048812 and neuron projection morphogenesis and biological process this GO :0051018 and protein kinase A binding and molecular function this GO :0051900 and regulation of mitochondrial depolarization and biological process this GO :0051966 and regulation of synaptic transmission, leucine-rich repeat kinase 2 |
| Identity: |
18618 |
| Gene: |
LRRK2 |
More about : LRRK2 |
| Long gene name: |
leucine rich repeat kinase 2 |
| Synonyms gene: |
PARK8 |
| Synonyms gene name: |
Parkinson disease (autosomal dominant) 8 |
| Synonyms: |
ROCO2 DKFZp434H2111 FLJ45829 RIPK7 |
| Locus: |
12q12 |
| Discovery year: |
2004-10-22 |
| GenBank acession: |
AK026776 |
| Entrez gene record: |
120892 |
| Pubmed identfication: |
15541308 |
| RefSeq identity: |
XM_058513 |
| Classification: |
Parkinson disease associated genes |
| Havana BLAST/BLAT: |
OTTHUMG00000059742 |
| Locus Specific Databases: |
Parkinson', s disease Mutation Database |