| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
PINK1 (PARK6) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus) , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, WB |
| Recommended dilutions: |
Western blot: 1:1000 |
| Notes: |
Titration of the PINK antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This PINK antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q9BXM7 |
| Purity: |
Purified |
| Description: |
About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease, Defects in PINK1 are the cause of autosomal recessive early-onset Parkinson's disease 6 (PARK6), PINK1 does not influence the cause of sporadic nonmendelian forms of PD, Strong evidence indicates that, although important in mendelian forms of Parkinson's disease (PD), Parkinson is the second most common neurodegenerative disease after Alzheimers |
| Immunogen: |
A portion of amino acids 237-266 from human PINK1 was used as the immunogen for this PINK antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the PINK antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
PINK1 (PARK6) |
| Short name: |
PINK1 Antibody (PARK6) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
phosphatase and tensin homolog induced putative kinase 1 (Antibody to) (PARK6) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
PINK1 and IDBG-645657 and ENSBTAG00000006084 and 510683, PINK1 and IDBG-92922 and ENSG00000158828 and 65018, Pink1 and IDBG-199773 and ENSMUSG00000028756 and 68943, dopaminergic and biological process this GO :0033603 and positive regulation of dopamine secretion and biological process this GO :0033605 and positive regulation of catecholamine secretion and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0043123 and positive regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0043254 and regulation of protein complex assembly and biological process this GO :0043523 and regulation of neuron apoptotic process and biological process this GO :0043524 and negative regulation of neuron apoptotic process and biological process this GO :0055131 and C3HC4-type RING finger domain binding and molecular function this GO :0090200 and positive regulation of release of cytochrome c from mitochondria and biological process this GO :0097237 and cellular response to toxic substance and biological process this GO :1902176 and negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway and biological process, nuclei, this GO :0000287 and magnesium ion binding and molecular function this GO :0000422 and mitochondrion degradation and biological process this GO :0000785 and chromatin and cellular component this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005741 and mitochondrial outer membrane and cellular component this GO :0005743 and mitochondrial inner membrane and cellular component this GO :0005758 and mitochondrial intermembrane space and cellular component this GO :0005829 and cytosol and cellular component this GO :0005856 and cytoskeleton and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006950 and response to stress and biological process this GO :0008219 and cell death and biological process this GO :0010857 and calcium-dependent protein kinase activity and molecular function this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016301 and kinase activity and molecular function this GO :0016567 and protein ubiquitination and biological process this GO :0016772 and transferase activity, this GO :0000287 : magnesium ion binding, this GO :0000287 : magnesium ion binding and also this GO :0004672 : protein kinase activity and also this GO :0004674 : protein serine/threonine kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0010857 : calcium-dependent protein kinase activity and also this GO :0016301 : kinase activity and also this GO :0016772 : transferase activity, this GO :0004672 : protein kinase activity, this GO :0004674 : protein serine/threonine kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0010857 : calcium-dependent protein kinase activity, this GO :0016301 : kinase activity, this GO :0016772 : transferase activity, this GO :0031625 : ubiquitin protein ligase binding, this GO :0055131 : C3HC4-type RING finger domain binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0031625 : ubiquitin protein ligase binding and also this GO :0055131 : C3HC4-type RING finger domain binding, transferring phosphorus-containing groups and molecular function this GO :0018105 and peptidyl-serine phosphorylation and biological process this GO :0031396 and regulation of protein ubiquitination and biological process this GO :0031625 and ubiquitin protein ligase binding and molecular function this GO :0032226 and positive regulation of synaptic transmission, PTEN induced putative kinase 1 |
| Identity: |
14581 |
| Gene: |
PINK1 |
More about : PINK1 |
| Long gene name: |
PTEN induced putative kinase 1 |
| Synonyms gene: |
PARK6 |
| Synonyms gene name: |
Parkinson disease (autosomal recessive) 6 |
| Locus: |
1p36, 12 |
| Discovery year: |
2001-02-08 |
| GenBank acession: |
AB053323 |
| Entrez gene record: |
65018 |
| Pubmed identfication: |
11494141 15349860 |
| RefSeq identity: |
NM_032409 |
| Classification: |
Parkinson disease associated genes |
| Havana BLAST/BLAT: |
OTTHUMG00000002841 |
| Locus Specific Databases: |
Parkinson', s disease Mutation Database |