| Long name: |
5) Monoclonal Antibody, 8, PINK1 (38CT20 |
| Also known as: |
5) Monoclonal Antibody, 8, PINK1 (38CT20 |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
PINK1 |
| Specificity: |
This is a highly specific antibody against PINK1 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
38CT20, 5, 8 |
| Source: |
Recombinant PINK1 protein was used to produced this monoclonal antibody |
| Gene ID number: |
65018 |
| Swiss Prot: |
Q9BXM7 |
| Tested Applications: |
IF, IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:25), WB(1:2000) |
| Cross reactivity: |
Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Activates PARK2 in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PARK2 and (2) mediating phosphorylation of ubiquitin, Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PARK2, PubMed:24751536, PubMed:24784582, PubMed:25527291), Targets PARK2 to dysfunctional depolarized mitochondria through the phosphorylation of MFN2, converting PARK2 to its fully-active form (PubMed:24660806, Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins |
| Purification method: |
This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS, 09% (W/V) sodium azide, Purified monoclonal antibody supplied in PBS with 0 |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
PARK6, PINK1, PTEN-induced putative kinase protein 1, Serine/threonine-protein kinase PINK1, mitochondrial, BRPK |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
5) Monoclonal, 8, PINK1 (38CT20 |
| Short name: |
5) Monoclonal Antibody, 8, PINK1 (38CT20 |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
5) monoclonal (Antibody to), 8, phosphatase and tensin homolog induced putative kinase 1 (38CT20 |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
PINK1 and IDBG-645657 and ENSBTAG00000006084 and 510683, PINK1 and IDBG-92922 and ENSG00000158828 and 65018, Pink1 and IDBG-199773 and ENSMUSG00000028756 and 68943, dopaminergic and biological process this GO :0033603 and positive regulation of dopamine secretion and biological process this GO :0033605 and positive regulation of catecholamine secretion and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0043123 and positive regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0043254 and regulation of protein complex assembly and biological process this GO :0043523 and regulation of neuron apoptotic process and biological process this GO :0043524 and negative regulation of neuron apoptotic process and biological process this GO :0055131 and C3HC4-type RING finger domain binding and molecular function this GO :0090200 and positive regulation of release of cytochrome c from mitochondria and biological process this GO :0097237 and cellular response to toxic substance and biological process this GO :1902176 and negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway and biological process, nuclei, this GO :0000287 and magnesium ion binding and molecular function this GO :0000422 and mitochondrion degradation and biological process this GO :0000785 and chromatin and cellular component this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005741 and mitochondrial outer membrane and cellular component this GO :0005743 and mitochondrial inner membrane and cellular component this GO :0005758 and mitochondrial intermembrane space and cellular component this GO :0005829 and cytosol and cellular component this GO :0005856 and cytoskeleton and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006950 and response to stress and biological process this GO :0008219 and cell death and biological process this GO :0010857 and calcium-dependent protein kinase activity and molecular function this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016301 and kinase activity and molecular function this GO :0016567 and protein ubiquitination and biological process this GO :0016772 and transferase activity, this GO :0000287 : magnesium ion binding, this GO :0000287 : magnesium ion binding and also this GO :0004672 : protein kinase activity and also this GO :0004674 : protein serine/threonine kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0010857 : calcium-dependent protein kinase activity and also this GO :0016301 : kinase activity and also this GO :0016772 : transferase activity, this GO :0004672 : protein kinase activity, this GO :0004674 : protein serine/threonine kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0010857 : calcium-dependent protein kinase activity, this GO :0016301 : kinase activity, this GO :0016772 : transferase activity, this GO :0031625 : ubiquitin protein ligase binding, this GO :0055131 : C3HC4-type RING finger domain binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0031625 : ubiquitin protein ligase binding and also this GO :0055131 : C3HC4-type RING finger domain binding, transferring phosphorus-containing groups and molecular function this GO :0018105 and peptidyl-serine phosphorylation and biological process this GO :0031396 and regulation of protein ubiquitination and biological process this GO :0031625 and ubiquitin protein ligase binding and molecular function this GO :0032226 and positive regulation of synaptic transmission, PTEN induced putative kinase 1 |
| Identity: |
14581 |
| Gene: |
PINK1 |
More about : PINK1 |
| Long gene name: |
PTEN induced putative kinase 1 |
| Synonyms gene: |
PARK6 |
| Synonyms gene name: |
Parkinson disease (autosomal recessive) 6 |
| Locus: |
1p36, 12 |
| Discovery year: |
2001-02-08 |
| GenBank acession: |
AB053323 |
| Entrez gene record: |
65018 |
| Pubmed identfication: |
11494141 15349860 |
| RefSeq identity: |
NM_032409 |
| Classification: |
Parkinson disease associated genes |
| Havana BLAST/BLAT: |
OTTHUMG00000002841 |
| Locus Specific Databases: |
Parkinson', s disease Mutation Database |