| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Leptin Receptor (LEPR) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, FACS, IHC, WB |
| Recommended dilutions: |
Flow Cytometry: 1:10-1:50, IHC (Paraffin): 1:50-1:100, Western blot: 1:1000 |
| Notes: |
Titration of the Leptin Receptor antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This Leptin Receptor antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P48357 |
| Purity: |
Purified |
| Description: |
During weight loss, LEPR is a single-transmembrane-domain receptor of the cytokine receptor family that is identical to the mouse diabetes (db) gene product, The presence of LEPR in the absorptive cells of the small intestine suggests that leptin may have a physiological role in the regulation of nutrient absorption, an adipocyte-specific hormone, leptin levels decrease, regulates adipose-tissue mass through hypothalamic effects on satiety and energy expenditure by acting through the leptin receptor (LEPR), whereas soluble LEPR levels and the receptor bound fraction of leptin increases, Leptin |
| Immunogen: |
A portion of amino acids 23-52 from the human protein was used as the immunogen for this Leptin Receptor antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the Leptin Receptor antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene: |
LEPR |
More about : LEPR |
| Gene target: |
Leptin Receptor (LEPR) |
| Short name: |
Leptin Receptor Antibody (LEPR) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Leptin Receptor (Antibody to) (leptin receptor) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
CD295 and LEP-R and LEPRD and OB-R and OBR, Extracellular, LEPR and IDBG-638266 and ENSBTAG00000005910 and 497205, LEPR and IDBG-99469 and ENSG00000116678 and 3953, Lepr and IDBG-167734 and ENSMUSG00000057722 and 16847, identical protein binding, this GO :0004888 and transmembrane signaling receptor activity and molecular function this GO :0004896 and cytokine receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006112 and energy reserve metabolic process and biological process this GO :0007166 and cell surface receptor signaling pathway and biological process this GO :0007275 and multicellular organismal development and biological process this GO :0008203 and cholesterol metabolic process and biological process this GO :0016021 and integral component of membrane and cellular component this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0042802 and identical protein binding and molecular function this GO :0043235 and receptor complex and cellular component this GO :0045721 and negative regulation of gluconeogenesis and biological process this GO :0051346 and negative regulation of hydrolase activity and biological process, this GO :0004888 : transmembrane signaling receptor activity, this GO :0004888 : transmembrane signaling receptor activity and also this GO :0004896 : cytokine receptor activity and also this GO :0005515 : protein binding and also this GO :0042802 : identical protein binding, this GO :0004896 : cytokine receptor activity, this GO :0005515 : protein binding, this GO :0042802 : identical protein binding, 785813, leptin receptor |
| Identity: |
6554 |
| Long gene name: |
leptin receptor |
| Synonyms: |
OBR CD295 |
| Locus: |
1p31, 3 |
| Discovery year: |
1996-05-09 |
| GenBank acession: |
U43168 |
| Entrez gene record: |
3953 |
| Pubmed identfication: |
8548812 8812446 |
| RefSeq identity: |
NM_002303 |
| Classification: |
CD molecules Immunoglobulin like domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000009115 |
| Locus Specific Databases: |
LRG_283 |