| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Leptin Receptor (LEPR) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus) , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, WB |
| Recommended dilutions: |
Western blot: 1:1000 |
| Notes: |
Titration of the Leptin Receptor antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This Leptin Receptor antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P48357 |
| Purity: |
Antigen affinity |
| Description: |
Alternatively spliced transcript variants encoding different isoforms have been described for this gene, It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, Mutations in this gene have been associated with obesity and pituitary dysfunction, This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis, encode distinct proteins (PMID:9207021), however, The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins |
| Immunogen: |
A portion of amino acids 957-986 from the human protein was used as the immunogen for this Leptin Receptor antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the Leptin Receptor antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene: |
LEPR |
More about : LEPR |
| Gene target: |
Leptin Receptor (LEPR) |
| Short name: |
Leptin Receptor Antibody (LEPR) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Leptin Receptor (Antibody to) (leptin receptor) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
CD295 and LEP-R and LEPRD and OB-R and OBR, Extracellular, LEPR and IDBG-638266 and ENSBTAG00000005910 and 497205, LEPR and IDBG-99469 and ENSG00000116678 and 3953, Lepr and IDBG-167734 and ENSMUSG00000057722 and 16847, identical protein binding, this GO :0004888 and transmembrane signaling receptor activity and molecular function this GO :0004896 and cytokine receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006112 and energy reserve metabolic process and biological process this GO :0007166 and cell surface receptor signaling pathway and biological process this GO :0007275 and multicellular organismal development and biological process this GO :0008203 and cholesterol metabolic process and biological process this GO :0016021 and integral component of membrane and cellular component this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0042802 and identical protein binding and molecular function this GO :0043235 and receptor complex and cellular component this GO :0045721 and negative regulation of gluconeogenesis and biological process this GO :0051346 and negative regulation of hydrolase activity and biological process, this GO :0004888 : transmembrane signaling receptor activity, this GO :0004888 : transmembrane signaling receptor activity and also this GO :0004896 : cytokine receptor activity and also this GO :0005515 : protein binding and also this GO :0042802 : identical protein binding, this GO :0004896 : cytokine receptor activity, this GO :0005515 : protein binding, this GO :0042802 : identical protein binding, 785813, leptin receptor |
| Identity: |
6554 |
| Long gene name: |
leptin receptor |
| Synonyms: |
OBR CD295 |
| Locus: |
1p31, 3 |
| Discovery year: |
1996-05-09 |
| GenBank acession: |
U43168 |
| Entrez gene record: |
3953 |
| Pubmed identfication: |
8548812 8812446 |
| RefSeq identity: |
NM_002303 |
| Classification: |
CD molecules Immunoglobulin like domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000009115 |
| Locus Specific Databases: |
LRG_283 |