| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Phospho-SHP2 (pY584) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, WB, DB |
| Recommended dilutions: |
Dot blot: 1:500, Western blot: 1:2000 |
| Notes: |
Titration of the phospho-SHP2 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This phospho-SHP2 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q06124 |
| Purity: |
Antigen affinity |
| Description: |
PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, This PTP contains two tandem Src homology-2 domains, This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, and cell migration, and oncogenic transformation, differentiation, metabolic control, mitotic cycle, such as mitogenic activation, transcription regulation, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates, SHP2 is a member of the protein tyrosine phosphatase (PTP) family |
| Immunogen: |
This phospho-SHP2 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pY584 of human SHP2 |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the phospho-SHP2 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
Phospho-SHP2 (pY584) |
| Short name: |
Phospho-SHP2 Antibody (pY584) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
phosphorilated-SHP2 (Antibody to) (pY584) |
| Alternative technique: |
antibodies |
| Identity: |
9644 |
| Gene: |
PTPN11 |
More about : PTPN11 |
| Long gene name: |
non-receptor type 11 , protein tyrosine phosphatase |
| Synonyms gene: |
NS1 |
| Synonyms gene name: |
Noonan syndrome 1 |
| Synonyms: |
BPTP3 SH-PTP2 SHP-2 PTP2C SHP2 |
| Locus: |
12q24, 13 |
| Discovery year: |
1993-03-03 |
| GenBank acession: |
D13540 |
| Entrez gene record: |
5781 |
| Pubmed identfication: |
7894486 1280823 |
| Classification: |
Protein tyrosine phosphatases, non-receptor type SH2 domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000134334 |
| Locus Specific Databases: |
LRG_614 |