| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
SHP2 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Titration of the SHP2 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This SHP2 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q06124 |
| Purity: |
Antigen affinity |
| Description: |
Mutations in this gene are a cause of Noonan syndromeas well as acute myeloid leukemia, PTPN11 is a member of the protein tyrosine phosphatase (PTP) family, PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, The open reading frame consists of 1, This PTP contains two tandem Src homology-2 domains, This PTP/SHP2 is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, also known as 'SH2 domain containing protein tyrosine phosphatase 2' (SHP2), and cell migration, and oncogenic transformation, differentiation, is an enzyme that in humans is encoded by the PTPN11 gene, metabolic control, mitotic cycle, such as mitogenic activation, transcription regulation, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates, 779 nucleotides potentially encoding a protein of 593 amino acids with a predicted molecular mass of 68 kD, PTPN11 (Tyrosine-protein phosphatase non-receptor type 11) |
| Immunogen: |
An amino acid sequence from the C-terminus of human SHP2 (RVYENVGLMQQQKSFR) was used as the immunogen for this SHP2 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the SHP2 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
SHP2 |
| Short name: |
SHP2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
SHP2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
9644 |
| Gene: |
PTPN11 |
More about : PTPN11 |
| Long gene name: |
non-receptor type 11 , protein tyrosine phosphatase |
| Synonyms gene: |
NS1 |
| Synonyms gene name: |
Noonan syndrome 1 |
| Synonyms: |
BPTP3 SH-PTP2 SHP-2 PTP2C SHP2 |
| Locus: |
12q24, 13 |
| Discovery year: |
1993-03-03 |
| GenBank acession: |
D13540 |
| Entrez gene record: |
5781 |
| Pubmed identfication: |
7894486 1280823 |
| Classification: |
Protein tyrosine phosphatases, non-receptor type SH2 domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000134334 |
| Locus Specific Databases: |
LRG_614 |