| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
RIG-I |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus) , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, WB |
| Recommended dilutions: |
Western blot: 1:1000 |
| Notes: |
Titration of the RIG-I antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This RIG-I antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
O95786 |
| Purity: |
Purified |
| Description: |
IRF3 and IRF7 and the induction of the expression of antiviral cytokines such as IFN-beta and RANTES (CCL5), It is involved in viral double-stranded (ds) RNA recognition and the innate immune defense against viruses, Japanese encephalitis virus and HCV, RIG-I contains RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD), RIG-I triggers a transduction cascade involving MAVS/IPS1, This protein is essential for the production of interferons in response to RNA viruses including paramyxoviruses, Upon interaction with intracellular dsRNA produced during viral replication, are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), influenza viruses, which results in the activation of NF-kappa-B, DEAD box proteins |
| Immunogen: |
A portion of amino acids 894-925 from the human protein was used as the immunogen for this RIG-I antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the RIG-I antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
RIG-I |
| Short name: |
RIG-I Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
RIG-I (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
19102 |
| Gene: |
DDX58 |
More about : DDX58 |
| Long gene name: |
DExD/H-box helicase 58 |
| Synonyms gene name: |
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 |
| Synonyms: |
RIG-I FLJ13599 DKFZp434J1111 |
| Synonyms name: |
RNA helicase RIG-I retinoic acid inducible gene I |
| Locus: |
9p21, 1 |
| Discovery year: |
2004-05-10 |
| GenBank acession: |
AF038963 |
| Entrez gene record: |
23586 |
| Pubmed identfication: |
21690088 |
| RefSeq identity: |
NM_014314 |
| Classification: |
DEAD-box helicases |
| Havana BLAST/BLAT: |
OTTHUMG00000019746 |