| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
COL1A1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus) , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, IHC, WB |
| Recommended dilutions: |
IHC (Paraffin): 1:10-1:50, Western blot: 1:1000 |
| Notes: |
Titration of the COL1A1 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This COL1A1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P02452 |
| Purity: |
Antigen affinity |
| Description: |
Caffey Disease and idiopathic osteoporosis, Dalgleish], Ehlers-Danlos syndrome Classical type, Ehlers-Danlos syndrome type VIIA, Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Reciprocal translocations between chromosomes 17 and 22, Two transcripts, Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, [provided by R, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, cornea, dermis and tendon, have been identified for this gene, resulting from the use of alternate polyadenylation signals, resulting from unregulated expression of the growth factor, where this gene and the gene for platelet-derived growth factor beta are located, This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain |
| Immunogen: |
A portion of amino acids 1077-1106 from the human protein was used as the immunogen for this COL1A1 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the COL1A1 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
COL1A1 |
| Short name: |
COL1A1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
a 1 (Antibody to), classification I, collagen |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
COL1A1 and IDBG-58238 and ENSG00000108821 and 1277, COL1A1 and IDBG-638637 and ENSBTAG00000013103 and 282187, Col1a1 and IDBG-209263 and ENSMUSG00000001506 and 12842, DNA-templated and biological process this GO :0046872 and metal ion binding and molecular function this GO :0048407 and platelet-derived growth factor binding and molecular function this GO :0048545 and response to steroid hormone and biological process this GO :0048705 and skeletal system morphogenesis and biological process this GO :0048706 and embryonic skeletal system development and biological process this GO :0050900 and leukocyte migration and biological process this GO :0051591 and response to cAMP and biological process this GO :0055093 and response to hyperoxia and biological process this GO :0060325 and face morphogenesis and biological process this GO :0060346 and bone trabecula formation and biological process this GO :0060351 and cartilage development involved in endochondral bone morphogenesis and biological process this GO :0070208 and protein heterotrimerization and biological process this GO :0071230 and cellular response to amino acid stimulus and biological process this GO :0071260 and cellular response to mechanical stimulus and biological process this GO :0071300 and cellular response to retinoic acid and biological process this GO :0071306 and cellular response to vitamin E and biological process this GO :0071356 and cellular response to tumor necrosis factor and biological process this GO :0071364 and cellular response to epidermal growth factor stimulus and biological process this GO :0071560 and cellular response to transforming growth factor beta stimulus and biological process this GO :0090263 and positive regulation of canonical Wnt signaling pathway and biological process this GO :1902617 and response to fluoride and biological process this GO :1902618 and cellular response to fluoride and biological process, Extracellular, OI4, alpha 1, platelet-derived growth factor binding, this GO :0001501 and skeletal system development and biological process this GO :0001503 and ossification and biological process this GO :0001568 and blood vessel development and biological process this GO :0001649 and osteoblast differentiation and biological process this GO :0001957 and intramembranous ossification and biological process this GO :0001958 and endochondral ossification and biological process this GO :0005201 and extracellular matrix structural constituent and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005578 and proteinaceous extracellular matrix and cellular component this GO :0005581 and collagen trimer and cellular component this GO :0005584 and collagen type I and cellular component this GO :0005615 and extracellular space and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005783 and endoplasmic reticulum and cellular component this GO :0005788 and endoplasmic reticulum lumen and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0007584 and response to nutrient and biological process this GO :0007596 and blood coagulation and biological process this GO :0007601 and visual perception and biological process this GO :0007605 and sensory perception of sound and biological process this GO :0009612 and response to mechanical stimulus and biological process this GO :0010718 and positive regulation of epithelial to mesenchymal transition and biological process this GO :0010812 and negative regulation of cell-substrate adhesion and biological process this GO :0015031 and protein transport and biological process this GO :0022617 and extracellular matrix disassembly and biological process this GO :0030141 and secretory granule and cellular component this GO :0030168 and platelet activation and biological process this GO :0030198 and extracellular matrix organization and biological process this GO :0030199 and collagen fibril organization and biological process this GO :0030335 and positive regulation of cell migration and biological process this GO :0030574 and collagen catabolic process and biological process this GO :0031012 and extracellular matrix and cellular component this GO :0031667 and response to nutrient levels and biological process this GO :0031960 and response to corticosteroid and biological process this GO :0032355 and response to estradiol and biological process this GO :0032964 and collagen biosynthetic process and biological process this GO :0034504 and protein localization to nucleus and biological process this GO :0034505 and tooth mineralization and biological process this GO :0042060 and wound healing and biological process this GO :0042493 and response to drug and biological process this GO :0042542 and response to hydrogen peroxide and biological process this GO :0042802 and identical protein binding and molecular function this GO :0043434 and response to peptide hormone and biological process this GO :0043588 and skin development and biological process this GO :0043589 and skin morphogenesis and biological process this GO :0044344 and cellular response to fibroblast growth factor stimulus and biological process this GO :0044691 and tooth eruption and biological process this GO :0045893 and positive regulation of transcription, this GO :0005201 : extracellular matrix structural constituent, this GO :0005201 : extracellular matrix structural constituent and also this GO :0005515 : protein binding and also this GO :0042802 : identical protein binding and also this GO :0046872 : metal ion binding and also this GO :0048407 : platelet-derived growth factor binding, this GO :0005515 : protein binding, this GO :0042802 : identical protein binding, this GO :0046872 : metal ion binding, this GO :0048407 : platelet-derived growth factor binding, type I, collagen |
| Identity: |
2197 |
| Gene: |
COL1A1 |
More about : COL1A1 |
| Long gene name: |
collagen type I alpha 1 chain |
| Synonyms gene name: |
alpha 1 , collagen, type I |
| Synonyms: |
OI4 |
| Locus: |
17q21, 33 |
| Discovery year: |
2001-06-22 |
| GenBank acession: |
Z74615 |
| Entrez gene record: |
1277 |
| Pubmed identfication: |
3178743 2857713 |
| RefSeq identity: |
NM_000088 |
| Classification: |
Collagens |
| Havana BLAST/BLAT: |
OTTHUMG00000148674 |
| Locus Specific Databases: |
Osteogenesis Imperfecta Variant Database LRG_1 |