| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Collagen Type 1 / COL1A1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
1-0, 5-1ug/ml, 5ug/ml, IHC (FFPE): 0, Western blot: 0 |
| Notes: |
Optimal dilution of the Collagen I antibody should be determined by the researcher |
| Intented use: |
This Collagen I antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P02452 |
| Purity: |
Antigen affinity |
| Description: |
And this gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain, Caffey Disease and idiopathic osteoporosis, Ehlers-Danlos syndrome Classical type, Ehlers-Danlos syndrome type VIIA, Mutations in this gene are associated with osteogenesis imperfecta types I-IV, This gene is mapped to 17q21, Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, alpha 1, also known as COL1A1, cornea, dermis and tendon, including cartilage, is a human gene that encodes the major component of type I collagen, the fibrillar collagen found in most connective tissues, type I, 33, Collagen |
| Immunogen: |
Amino acids AGFDFSFLPQPPQEKAHDGGRYYRA were used as the immunogen for the Collagen I antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the Collagen I antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term |
| Localization: |
Cytoplasmic |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
Collagen 1 / COL1A1 |
| Short name: |
Collagen 1 Antibody / COL1A1 |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
a 1, classification I, Collagen classification 1 (Antibody to) / collagen |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
COL1A1 and IDBG-58238 and ENSG00000108821 and 1277, COL1A1 and IDBG-638637 and ENSBTAG00000013103 and 282187, Col1a1 and IDBG-209263 and ENSMUSG00000001506 and 12842, DNA-templated and biological process this GO :0046872 and metal ion binding and molecular function this GO :0048407 and platelet-derived growth factor binding and molecular function this GO :0048545 and response to steroid hormone and biological process this GO :0048705 and skeletal system morphogenesis and biological process this GO :0048706 and embryonic skeletal system development and biological process this GO :0050900 and leukocyte migration and biological process this GO :0051591 and response to cAMP and biological process this GO :0055093 and response to hyperoxia and biological process this GO :0060325 and face morphogenesis and biological process this GO :0060346 and bone trabecula formation and biological process this GO :0060351 and cartilage development involved in endochondral bone morphogenesis and biological process this GO :0070208 and protein heterotrimerization and biological process this GO :0071230 and cellular response to amino acid stimulus and biological process this GO :0071260 and cellular response to mechanical stimulus and biological process this GO :0071300 and cellular response to retinoic acid and biological process this GO :0071306 and cellular response to vitamin E and biological process this GO :0071356 and cellular response to tumor necrosis factor and biological process this GO :0071364 and cellular response to epidermal growth factor stimulus and biological process this GO :0071560 and cellular response to transforming growth factor beta stimulus and biological process this GO :0090263 and positive regulation of canonical Wnt signaling pathway and biological process this GO :1902617 and response to fluoride and biological process this GO :1902618 and cellular response to fluoride and biological process, Extracellular, OI4, alpha 1, platelet-derived growth factor binding, this GO :0001501 and skeletal system development and biological process this GO :0001503 and ossification and biological process this GO :0001568 and blood vessel development and biological process this GO :0001649 and osteoblast differentiation and biological process this GO :0001957 and intramembranous ossification and biological process this GO :0001958 and endochondral ossification and biological process this GO :0005201 and extracellular matrix structural constituent and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005578 and proteinaceous extracellular matrix and cellular component this GO :0005581 and collagen trimer and cellular component this GO :0005584 and collagen type I and cellular component this GO :0005615 and extracellular space and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005783 and endoplasmic reticulum and cellular component this GO :0005788 and endoplasmic reticulum lumen and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0007584 and response to nutrient and biological process this GO :0007596 and blood coagulation and biological process this GO :0007601 and visual perception and biological process this GO :0007605 and sensory perception of sound and biological process this GO :0009612 and response to mechanical stimulus and biological process this GO :0010718 and positive regulation of epithelial to mesenchymal transition and biological process this GO :0010812 and negative regulation of cell-substrate adhesion and biological process this GO :0015031 and protein transport and biological process this GO :0022617 and extracellular matrix disassembly and biological process this GO :0030141 and secretory granule and cellular component this GO :0030168 and platelet activation and biological process this GO :0030198 and extracellular matrix organization and biological process this GO :0030199 and collagen fibril organization and biological process this GO :0030335 and positive regulation of cell migration and biological process this GO :0030574 and collagen catabolic process and biological process this GO :0031012 and extracellular matrix and cellular component this GO :0031667 and response to nutrient levels and biological process this GO :0031960 and response to corticosteroid and biological process this GO :0032355 and response to estradiol and biological process this GO :0032964 and collagen biosynthetic process and biological process this GO :0034504 and protein localization to nucleus and biological process this GO :0034505 and tooth mineralization and biological process this GO :0042060 and wound healing and biological process this GO :0042493 and response to drug and biological process this GO :0042542 and response to hydrogen peroxide and biological process this GO :0042802 and identical protein binding and molecular function this GO :0043434 and response to peptide hormone and biological process this GO :0043588 and skin development and biological process this GO :0043589 and skin morphogenesis and biological process this GO :0044344 and cellular response to fibroblast growth factor stimulus and biological process this GO :0044691 and tooth eruption and biological process this GO :0045893 and positive regulation of transcription, this GO :0005201 : extracellular matrix structural constituent, this GO :0005201 : extracellular matrix structural constituent and also this GO :0005515 : protein binding and also this GO :0042802 : identical protein binding and also this GO :0046872 : metal ion binding and also this GO :0048407 : platelet-derived growth factor binding, this GO :0005515 : protein binding, this GO :0042802 : identical protein binding, this GO :0046872 : metal ion binding, this GO :0048407 : platelet-derived growth factor binding, type I, collagen |
| Identity: |
2197 |
| Gene: |
COL1A1 |
More about : COL1A1 |
| Long gene name: |
collagen type I alpha 1 chain |
| Synonyms gene name: |
alpha 1 , collagen, type I |
| Synonyms: |
OI4 |
| Locus: |
17q21, 33 |
| Discovery year: |
2001-06-22 |
| GenBank acession: |
Z74615 |
| Entrez gene record: |
1277 |
| Pubmed identfication: |
3178743 2857713 |
| RefSeq identity: |
NM_000088 |
| Classification: |
Collagens |
| Havana BLAST/BLAT: |
OTTHUMG00000148674 |
| Locus Specific Databases: |
Osteogenesis Imperfecta Variant Database LRG_1 |