| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
LSD1 (Nuclear envelope marker) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, IHC, WB |
| Recommended dilutions: |
IHC (Paraffin): 1:50-1:100, Western blot: 1:1000 |
| Notes: |
Titration of the LSD1 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This LSD1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
O60341 |
| Purity: |
Purified |
| Description: |
Alone, It acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed, It may also demethylate 'Lys-9' of histone H3, LSD1 contains a SWIRM domain, LSD1 demethylates both mono- and tri-methylted 'Lys-4' of histone H3, This protein is a component of several histone deacetylase complexes, This protein may play a role in the repression of neuronal genes, a FAD-binding motif, a specific tag for epigenetic transcriptional activation, a specific tag for epigenetic transcriptional repression, and an amine oxidase domain, it is unable to demethylate H3 'Lys-4' on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity, thereby acting as a corepressor, thereby leading to derepression of androgen receptor target genes, though it silences genes by functioning as a histone demethylase, LSD1 is a histone demethylase that specifically demethylates 'Lys-4' of histone H3 |
| Immunogen: |
A portion of amino acids 457-490 from the human protein was used as the immunogen for this LSD1 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the LSD1 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene: |
KDM1A |
More about : KDM1A |
| Gene target: |
LSD1 envelope |
| Short name: |
LSD1 Antibody (Nuclear envelope ) |
| Technique: |
Component cell markers and DNA bp, Protein markers in kDA, antibodies against human proteins, antibodies for, markers are , Antibody, DNA sequences , chromosome , er genes or , genetic markers , species, that can be used to identify individuals or , with a known location on a |
| Alternative name: |
LSD1 (Antibody to) (Nuclear envelope detection labelled) |
| Alternative technique: |
antibodies |
| Identity: |
29079 |
| Long gene name: |
lysine demethylase 1A |
| Synonyms gene: |
AOF2 KDM1 |
| Synonyms gene name: |
amine oxidase (flavin containing) domain 2 lysine (K)-specific demethylase 1 |
| Synonyms: |
KIAA0601 BHC110 LSD1 |
| Locus: |
1p36, 12 |
| Discovery year: |
2004-02-26 |
| GenBank acession: |
AL031428 |
| Entrez gene record: |
23028 |
| Pubmed identfication: |
9628581 12493763 |
| RefSeq identity: |
NM_015013 |
| Classification: |
Lysine demethylases |
| Havana BLAST/BLAT: |
OTTHUMG00000003220 |