| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
TRPM8 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, IHC, WB |
| Recommended dilutions: |
IHC (Paraffin): 1:50-1:100, Western blot: 1:1000 |
| Notes: |
Titration of the TRPM8 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This TRPM8 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q7Z2W7 |
| Purity: |
Purified |
| Description: |
Activated by icilin, Activated upon depolarization, Involved in menthol sensation, Permeable for monovalent cations sodium, Temperature sensing is tightly linked to voltage-dependent gating, Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing, The chemical agonists menthol functions as a gating modifier, and cesium and divalent cation calcium, by being activated by cold temperature below 25 degrees Celsius, changes in temperature resulting in graded shifts of its voltage-dependent activation curves, cold and modulation of intracellular pH, eucalyptol, menthol, potassium, shifting activation curves towards physiological membrane potentials, Receptor-activated non-selective cation channel involved in detection of sensations such as coolness |
| Immunogen: |
A portion of amino acids 69-98 from the human protein was used as the immunogen for this TRPM8 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the TRPM8 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
TRPM8 |
| Short name: |
TRPM8 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
TRPM8 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
17961 |
| Gene: |
TRPM8 |
More about : TRPM8 |
| Long gene name: |
transient receptor potential cation channel subfamily M member 8 |
| Synonyms gene name: |
member 8 , subfamily M, transient receptor potential cation channel |
| Locus: |
2q37, 1 |
| Discovery year: |
2002-01-11 |
| GenBank acession: |
AC005538 |
| Entrez gene record: |
79054 |
| Pubmed identfication: |
16382100 |
| RefSeq identity: |
NM_024080 |
| Classification: |
Transient receptor potential cation channels |
| Havana BLAST/BLAT: |
OTTHUMG00000059129 |