| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
IRF1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, WB |
| Recommended dilutions: |
Western blot: 1:1000 |
| Notes: |
Titration of the IRF1 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This IRF1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P10914 |
| Purity: |
Antigen affinity |
| Description: |
Further, IRF1 also functions as a transcription activator of genes induced by interferons alpha, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion, IRF1 serves as an activator of interferons alpha and beta transcription, a member of the interferon regulatory transcription factor (IRF) family, and gamma, and in mouse it has been shown to be required for double-stranded RNA induction of these genes, beta, IRF1 encodes interferon regulatory factor 1 |
| Immunogen: |
A portion of amino acids 260-286 from the human protein was used as the immunogen for this IRF1 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the IRF1 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
IRF1 |
| Short name: |
IRF1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
interferon regulatory factor 1 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
DNA-templated and biological process this GO :0006366 and transcription from RNA polymerase II promoter and biological process this GO :0006915 and apoptotic process and biological process this GO :0007050 and cell cycle arrest and biological process this GO :0007596 and blood coagulation and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0010468 and regulation of gene expression and biological process this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0032481 and positive regulation of type I interferon production and biological process this GO :0032728 and positive regulation of interferon-beta production and biological process this GO :0034124 and regulation of MyD88-dependent toll-like receptor signaling pathway and biological process this GO :0035458 and cellular response to interferon-beta and biological process this GO :0043374 and CD8-positive, DNA-templated and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0051607 and defense response to virus and biological process this GO :0051726 and regulation of cell cycle and biological process this GO :0060333 and interferon-gamma-mediated signaling pathway and biological process this GO :0060337 and type I interferon signaling pathway and biological process this GO :0071260 and cellular response to mechanical stimulus and biological process this GO :2000564 and regulation of CD8-positive, IRF-1 and MAR, IRF1 and IDBG-42125 and ENSG00000125347 and 3659, IRF1 and IDBG-644680 and ENSBTAG00000031231 and 337917, Irf1 and IDBG-172251 and ENSMUSG00000018899 and 16362, alpha-beta T cell differentiation and biological process this GO :0043565 and sequence-specific DNA binding and molecular function this GO :0045084 and positive regulation of interleukin-12 biosynthetic process and biological process this GO :0045087 and innate immune response and biological process this GO :0045088 and regulation of innate immune response and biological process this GO :0045590 and negative regulation of regulatory T cell differentiation and biological process this GO :0045892 and negative regulation of transcription, alpha-beta T cell proliferation and biological process, nuclei, sequence-specific DNA binding, this GO :0000790 and nuclear chromatin and cellular component this GO :0000975 and regulatory region DNA binding and molecular function this GO :0000978 and RNA polymerase II core promoter proximal region sequence-specific DNA binding and molecular function this GO :0002819 and regulation of adaptive immune response and biological process this GO :0003677 and DNA binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006355 and regulation of transcription, this GO :0000975 : regulatory region DNA binding, this GO :0000975 : regulatory region DNA binding and also this GO :0000978 : RNA polymerase II core promoter proximal region sequence-specific DNA binding and also this GO :0003677 : DNA binding and also this GO :0003700 : sequence-specific DNA binding transcription factor activity and also this GO :0005515 : protein binding and also this GO :0043565 : sequence-specific DNA binding, this GO :0000978 : RNA polymerase II core promoter proximal region sequence-specific DNA binding, this GO :0003677 : DNA binding, this GO :0003700 : sequence-specific DNA binding transcription factor activity, this GO :0005515 : protein binding, this GO :0043565 : sequence-specific DNA binding, 789216, interferon regulatory factor 1 |
| Identity: |
6116 |
| Gene: |
IRF1 |
More about : IRF1 |
| Long gene name: |
interferon regulatory factor 1 |
| Synonyms: |
MAR |
| Synonyms name: |
interferon regulatory factor-1 |
| Locus: |
5q31, 1 |
| Discovery year: |
1991-05-09 |
| Entrez gene record: |
3659 |
| Pubmed identfication: |
2726461 1680796 |
| RefSeq identity: |
NM_002198 |
| Havana BLAST/BLAT: |
OTTHUMG00000059497 |