| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
IRF1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ICC, IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Immunocytochemistry: 0, Western blot: 0 |
| Notes: |
Titration of the IRF1 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This IRF1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P10914 |
| Purity: |
Antigen affinity |
| Description: |
Further, IRF1 encodes interferon regulatory factor 1, IRF1 has been shown to play roles in regulating apoptosis and tumor suppression, IRF1 serves as an activator of interferons alpha and beta transcription, It also functions as a transcription activator of genes induced by interferons alpha, a member of the interferon regulatory transcription factor (IRF) family, also known as MAR, and gamma, and in mouse it has been shown to be required for double-stranded RNA induction of these genes, beta, is a protein that in humans is encoded by the IRF1 gene, Interferon regulatory factor 1 |
| Immunogen: |
An amino acid sequence from the middle region of human Interferon regulatory factor 1 (YMQDLEVEQALTPAL) was used as the immunogen for this IRF1 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the IRF1 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
IRF1 |
| Short name: |
IRF1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
interferon regulatory factor 1 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
DNA-templated and biological process this GO :0006366 and transcription from RNA polymerase II promoter and biological process this GO :0006915 and apoptotic process and biological process this GO :0007050 and cell cycle arrest and biological process this GO :0007596 and blood coagulation and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0010468 and regulation of gene expression and biological process this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0032481 and positive regulation of type I interferon production and biological process this GO :0032728 and positive regulation of interferon-beta production and biological process this GO :0034124 and regulation of MyD88-dependent toll-like receptor signaling pathway and biological process this GO :0035458 and cellular response to interferon-beta and biological process this GO :0043374 and CD8-positive, DNA-templated and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0051607 and defense response to virus and biological process this GO :0051726 and regulation of cell cycle and biological process this GO :0060333 and interferon-gamma-mediated signaling pathway and biological process this GO :0060337 and type I interferon signaling pathway and biological process this GO :0071260 and cellular response to mechanical stimulus and biological process this GO :2000564 and regulation of CD8-positive, IRF-1 and MAR, IRF1 and IDBG-42125 and ENSG00000125347 and 3659, IRF1 and IDBG-644680 and ENSBTAG00000031231 and 337917, Irf1 and IDBG-172251 and ENSMUSG00000018899 and 16362, alpha-beta T cell differentiation and biological process this GO :0043565 and sequence-specific DNA binding and molecular function this GO :0045084 and positive regulation of interleukin-12 biosynthetic process and biological process this GO :0045087 and innate immune response and biological process this GO :0045088 and regulation of innate immune response and biological process this GO :0045590 and negative regulation of regulatory T cell differentiation and biological process this GO :0045892 and negative regulation of transcription, alpha-beta T cell proliferation and biological process, nuclei, sequence-specific DNA binding, this GO :0000790 and nuclear chromatin and cellular component this GO :0000975 and regulatory region DNA binding and molecular function this GO :0000978 and RNA polymerase II core promoter proximal region sequence-specific DNA binding and molecular function this GO :0002819 and regulation of adaptive immune response and biological process this GO :0003677 and DNA binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006355 and regulation of transcription, this GO :0000975 : regulatory region DNA binding, this GO :0000975 : regulatory region DNA binding and also this GO :0000978 : RNA polymerase II core promoter proximal region sequence-specific DNA binding and also this GO :0003677 : DNA binding and also this GO :0003700 : sequence-specific DNA binding transcription factor activity and also this GO :0005515 : protein binding and also this GO :0043565 : sequence-specific DNA binding, this GO :0000978 : RNA polymerase II core promoter proximal region sequence-specific DNA binding, this GO :0003677 : DNA binding, this GO :0003700 : sequence-specific DNA binding transcription factor activity, this GO :0005515 : protein binding, this GO :0043565 : sequence-specific DNA binding, 789216, interferon regulatory factor 1 |
| Identity: |
6116 |
| Gene: |
IRF1 |
More about : IRF1 |
| Long gene name: |
interferon regulatory factor 1 |
| Synonyms: |
MAR |
| Synonyms name: |
interferon regulatory factor-1 |
| Locus: |
5q31, 1 |
| Discovery year: |
1991-05-09 |
| Entrez gene record: |
3659 |
| Pubmed identfication: |
2726461 1680796 |
| RefSeq identity: |
NM_002198 |
| Havana BLAST/BLAT: |
OTTHUMG00000059497 |