| Gene info: |
Considerable attention has been focused on the distribution and expression of these splice variants that may affect the functional properties and regulation of the NMDAR, Differential splicing of three exons in the NR1 subunit generates up to eight NR1 splice variants and 7 of these have been identified in cDNA libraries, Increased membrane surface expression of the NR1 subunit of the receptor has been associated with synaptic plasticity, Splicing out the C2 cassette eliminates the first stop codon and produces a new reading frame that generates a new sequence of 22 amino acids (C2'), The NMDAR plays an essential role in memory, There are a number of different splice variants of the NR1, These exons encode a 21 amino acid N-terminal domain (N1) and adjacent sequences in the C-terminus (C1 and C2), Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR), epilepsy and ischemic neuronal cell death, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer&rsquo, The ion channels activated by glutamate are typically divided into two classes, s disease |
| Gene names: |
GluN1, N-methyl-D-aspartate receptor subunit NR1, NMDAR1, Nmdar1, NR1 |
| Antibodie's label: |
unlabelled serum |
| Purity: |
Affinity Purified |
| Ab raised in: |
Rabbit |
| Type: |
Polyclonal |
| Antigen: |
Splice Variant N1 polyclonal antibody was made against a peptide containing the N1 insert, NMDA NR1 |
| Immuno application: |
immuno-histo-chemistry, Western Blot |
| Antibody advice: |
Applications include Dot Blots (DB), DB and WB, Immunohistochemistry (IHC) and Western Blots (WB), Rabbit anti-NMDA NR1, Splice Variant N1 antibody allows for strong and specific immunolabeling of the NR1 subunit containing the N1 splice variant insert, Splice Variant N1 recognizes NR1 in rat and mouse brain, This product does not recognize NR1 subunits that do not contain the N1 insert, When internally tested under ideal conditions the working dilutions were 1:1000 for IHC, NMDA NR1 |
| Keep at: |
After reconstitution in 50 &, Ambient shipment is suitable for both international and domestic, Splice Variant N1 antibody can be stored at -20 grades C, the antibody should be aliquot and stored at -20 grades C and is stable at -20 grades C for at least 1 year, #956, NMDA NR1, l PBS |
| Works with: |
Rat |
| Omim nr: |
548379 |
| Ncbi nr: |
P35439 |
| KDa: |
120 |
| Vial with antibody: |
Lyophilized |
| NCBI GENE nr: |
24408 |
| GENE symbol: |
Grin1 |
| Antigene name: |
N-methyl D-aspartate 1, ionotropic, glutamate receptor |
| Source: |
Rattus norvegicus |
| Protein nr: |
P35439 |
| Description: |
Freeze thaw will destroy a percentage in every cycle and should be avoided, C in a fridge short term in a concentrated dilution, This antibody needs to be stored at + 4° |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by proscience they should be stored frozen at - 24° |
| Gene target: |
NMDA NR1 |
| Short name: |
anti-NMDA NR1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody to, Antibody |
| Alternative name: |
antibody to-NMDA NR1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
4584 |
| Gene: |
GRIN1 |
More about : GRIN1 |
| Long gene name: |
glutamate ionotropic receptor NMDA type subunit 1 |
| Synonyms gene: |
NMDAR1 |
| Synonyms gene name: |
N-methyl D-aspartate 1 , N-methyl-D-aspartate receptor subunit NR1 glutamate receptor, ionotropic |
| Synonyms: |
GluN1 |
| Locus: |
9q34, 3 |
| Discovery year: |
1992-09-18 |
| Entrez gene record: |
2902 |
| Pubmed identfication: |
1350383 |
| RefSeq identity: |
NM_007327 |
| Classification: |
Glutamate ionotropic receptor NMDA type subunits |
| Havana BLAST/BLAT: |
OTTHUMG00000020976 |