| Gene info: |
Overexpression of the NR2B subunit of the receptor has been associated with increases in learning and memory while aged, The NMDAR plays an essential role in memory, Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR), Tyr1472 on NR2B is phosphorylated and this may lead to the increased expression of the NMDAR at the synapse that plays a role in synaptic plasticity, epilepsy and ischemic neuronal cell death, memory impaired animals have deficiencies in NR2B expression, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer&rsquo, The ion channels activated by glutamate are typically divided into two classes, s |
| Gene names: |
GluN2B, N-methyl D-aspartate receptor subtype 2B, GluN2B |
| Antibodie's label: |
unlabelled serum |
| Purity: |
Affinity Purified |
| Ab raised in: |
Rabbit |
| Type: |
Polyclonal |
| Spicific to: |
NMDA antibody is specific for ~180 kD NMDAR NR2B phosphorylated at Tyr1472 |
| Antigen: |
NMDA NR2B (Tyr1472) polyclonal antibody was made against a synthetic phosphopeptide corresponding to amino acids residues surrounding the phosphorylated Tyr1472 of rat NMDA NR2B |
| Immuno application: |
Western Blot |
| Antibody advice: |
Applications include Dot Blots (DB) and Western Blots (WB), Human, The antibody also labels bands at 65k and 115k, When internally tested under ideal conditions the working dilutions were 1:1000 for DB and WB, and rat have 100% amino acid sequence identity with the antigen used to raise the antibody, mouse, The labeling of the NR2B protein in Western blots of rat brain is blocked by the phosphopeptide but not by the dephosphopeptide |
| Suspention, pH, azide: |
100 ug per mL BSA and 50% glycerol, 150 mM NaCl, 100 uL in 10 mM HEPES (pH 7, 5) |
| Keep at: |
Stable for one year, but shorter term storage at &ndash, 20 grades C is also acceptable as aliquots may be taken without freeze/thawing due to the presence of 50% glycerol, 80 grades C is recommended, For long term storage &ndash |
| Works with: |
Mouse, Rat, Human |
| Omim nr: |
548372 |
| Ncbi nr: |
Q00960 |
| KDa: |
180 |
| Vial with antibody: |
in solution |
| NCBI GENE nr: |
24410 |
| GENE symbol: |
Grin2b |
| Antigene name: |
N-methyl D-aspartate 2B, ionotropic, glutamate receptor |
| Source: |
Rattus norvegicus |
| Protein nr: |
Q00960 |
| Description: |
Freeze thaw will destroy a percentage in every cycle and should be avoided, C in a fridge short term in a concentrated dilution, This antibody needs to be stored at + 4° |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by proscience they should be stored frozen at - 24° |
| Gene target: |
NMDA NR2B (phospho Tyr1472) |
| Short name: |
anti-NMDA NR2B (phospho Tyr1472) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody to, Antibody |
| Alternative name: |
antibody to-NMDA NR2B (phosphorilated Tyr1472) (Antibody to) |
| Alternative technique: |
antibodies |