| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
CACNA1S |
| Specificity: |
This antibody reacts specifically with CACNA1S |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human CACNA1S |
| Gene ID: |
779 |
| Swiss Prot: |
Q13698 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle, Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group, The isoform alpha-1S gives rise to L-type calcium currents, They are blocked by dihydropyridines (DHP), They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA), and by omega-agatoxin-IIIA (omega-Aga-IIIA), benzothiazepines, cell division and cell death, cell motility, gene expression, hormone or neurotransmitter release, including muscle contraction, phenylalkylamines, Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
Cav1, 1 hypoPP |
| Also known as: |
CACNA1S Polyclonal Antibody |
| Other name: |
Anti-CACNA1S Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
CACNA1S |
| Short name: |
Anti-CACNA1S (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-CACNA1S (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
1397 |
| Gene: |
CACNA1S |
More about : CACNA1S |
| Long gene name: |
calcium voltage-gated channel subunit alpha1 S |
| Synonyms gene: |
HOKPP MHS5 CACNL1A3 |
| Synonyms gene name: |
L type, alpha 1S subunit , calcium channel, voltage-dependent |
| Locus: |
1q32, 1 |
| Discovery year: |
1992-03-27 |
| GenBank acession: |
L33798 |
| Entrez gene record: |
779 |
| Pubmed identfication: |
7916735 16382099 |
| RefSeq identity: |
NM_000069 |
| Classification: |
Calcium voltage-gated channel subunits |
| Havana BLAST/BLAT: |
OTTHUMG00000035784 |
| Locus Specific Databases: |
LOVD - Leiden Open Variation Database |