| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
UVRAG |
| Specificity: |
This antibody reacts specifically with UVRAG |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human UVRAG/DHTX |
| Gene ID: |
7405 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Autophagy is the degradation of cellular proteins in the lysosomes, Mutations in the gene encoding UVRAG have been associated with colon cancer, UVRAG contains one C2 domain, UVRAG has been found to complement the ultraviolet sensitivity of xeroderma pigmentosum group C cells, UVRAG has been shown to activate the BECN1/PI 3-kinase complex, UVRAG is found at highest levels in kidney, Ubiquitously expressed, also known as p63 or DHTX, and when this pathway is suppressed, cell growth is deregulated, is a 699 amino acid cytoplasmic protein, liver and brain, lung, suggesting that UVRAG is also involved in suppressing the proliferation and tumorigenicity of human colon cancer cells, which is thought to be involved in calcium-dependent phospholipid binding, which promotes autophagy, UVRAG |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
VPS38 |
| Also known as: |
UVRAG Polyclonal Antibody |
| Other name: |
Anti-UVRAG Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
UVRAG |
| Short name: |
Anti-UVRAG (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-UVRAG (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
12640 |
| Gene: |
UVRAG |
More about : UVRAG |
| Long gene name: |
UV radiation resistance associated |
| Synonyms gene name: |
UV radiation resistance associated gene |
| Synonyms name: |
beclin 1 binding protein |
| Locus: |
11q13, 5 |
| Discovery year: |
1997-01-10 |
| GenBank acession: |
X99050 AB012958 |
| Entrez gene record: |
7405 |
| Pubmed identfication: |
9169138 16799551 18843052 |
| RefSeq identity: |
NM_003369 |
| Classification: |
C2 domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000165319 |