| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
SIP1 |
| Specificity: |
This antibody reacts specifically with SIP1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Nucleus |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human SIP1 |
| Gene ID: |
9839 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Mutations in the SIP1 gene cause a form of Hirschsprung disease (HSCR), Patients with SIP1 mutations show mental retardation, SIP1, SIP1, SIP1 contains a SMAD-binding domain, SIP1 plays a crucial role in normal embryonic development of neural structures and the neural crest, The human SIP1 gene maps to chromosome 2q22, ZFHX1B and ZEB2 (zinc finger E-box-binding protein 2), a homeodomain and two clusters of zinc fingers on the N- and C-termini, also known as SMADIP1, can be induced by TGFâ, delayed motor development, distinct facial features and/or congenital heart diseaseâ, epilepsy, for SMAD interacting protein 1, is a member of the delta-EF1/Zfh1 family of 2-handed zinc finger/homeodomain proteins, microcephaly, treatment, &circ, &euro, «, &rdquo, SMAD regulates gene expression by interacting with different classes of transcription factors including DNA-binding multi-zinc finger proteins, all symptoms of HSCR |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Also known as: |
SIP1 Polyclonal Antibody |
| Other name: |
Anti-SIP1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
SIP1 |
| Short name: |
Anti-SIP1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-SIP1 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
10884 |
| Gene: |
GEMIN2 |
More about : GEMIN2 |
| Long gene name: |
gem nuclear organelle associated protein 2 |
| Synonyms gene: |
SIP1 |
| Synonyms gene name: |
survival of motor neuron protein interacting protein 1 gem (nuclear organelle) associated protein 2 |
| Locus: |
14q21, 1 |
| Discovery year: |
1998-10-16 |
| GenBank acession: |
AF027150 |
| Entrez gene record: |
8487 |
| Pubmed identfication: |
9323130 9323129 11121410 |
| Classification: |
Gemins |
| Havana BLAST/BLAT: |
OTTHUMG00000028816 |