| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
RNF92 |
| Specificity: |
This antibody reacts specifically with RNF92 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human TRIM11/RNF92 |
| Gene ID: |
81559 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain, May also inhibit PAX6 transcriptional activity, May contribute to the innate restriction of retroviruses, May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway, May regulate TRIM5 turnover via the proteasome pathway, Mediates MED15 ubiquitination leading to proteasomal degradation, Mediates PAX6 ubiquitination leading to proteasomal degradation, Upon overexpression, by suppressing viral gene expression, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX, possibly in part by preventing the binding of PAX6 to its consensus sequences, reduces HIV-1 and murine leukemia virus infectivity, thereby modulating cortical neurogenesis, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle, E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
RNF92 BIA1 |
| Also known as: |
RNF92 Polyclonal Antibody |
| Other name: |
Anti-RNF92 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
RNF92 |
| Short name: |
Anti-RNF92 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-RNF92 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
16281 |
| Gene: |
TRIM11 |
More about : TRIM11 |
| Long gene name: |
tripartite motif containing 11 |
| Synonyms gene name: |
tripartite motif-containing 11 |
| Locus: |
1q42, 13 |
| Discovery year: |
2001-08-07 |
| GenBank acession: |
AF220125 |
| Entrez gene record: |
81559 |
| Pubmed identfication: |
11331580 |
| RefSeq identity: |
NM_145214 |
| Classification: |
Tripartite motif containing Ring finger proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000039773 |