| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Ecadherin binding protein E7 |
| Specificity: |
This antibody reacts specifically with Ecadherin binding protein E7 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human CBLL1/Ecadherin binding protein E7 |
| Gene ID: |
79872 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
CBLL1 interacts with and ubiquitinates tyrosine-phosphorylated E-cadherin, CBLL1 is believed to function as an E3 ubiquitin-protein ligase that accepts a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and immediately transfers that residue to a protein that is targeted for degradation, CBLL1 participates in cell adhesion and may also be involved in the regulation of epithelial-mesenchymal transitions, More specifically, Via its role as an E-cadherin regulator, also known as HAKAI (meaning â, in Japanese), is a 491 amino acid protein that contains one C2H2-type zinc finger and one RING-type zinc finger, or RNF188 (RING finger protein 188), thereby targeting the E-cadherin complex for endocytosis and disrupting epithelial cell-cell contacts, upon activation of c-Src, &euro, &euro, &tilde, &trade, CBLL1, destructionâ |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
CasBrM murine ecotropic retroviral transforming sequencelike 1, Casitas B-lineage lymphoma transforming sequence-like protein 1, Casitas B-lineage lymphoma-like 1, Casitas B-lineage lymphoma-transforming sequence-like protein 1, E3 ubiquitin-protein ligase Hakai, Ecadherin binding protein E7, FLJ23109, HAKAI, HAKAI_HUMAN, MGC163401, MGC163403, OTTHUMP00000206720, OTTHUMP00000206722, OTTHUMP00000206724, RING finger protein 188, RNF188, cbll1, c-Cbl-like protein 1 |
| Also known as: |
Ecadherin binding protein E7 Antibody |
| Other name: |
Anti-Ecadherin binding protein E7 |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
Ecadherin binding protein E7 |
| Short name: |
Fluor 594, Anti-Ecadherin binding protein E7 |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Ecadherin binding protein E7 |