| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
STK3+STK4 |
| Specificity: |
This antibody reacts specifically with STK3+STK4 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Helical |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human STK3 |
| Gene ID: |
6788, 6789 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis, The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation, following caspase-cleavage, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, pro-apoptotic kinase which, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ, Stress-activated |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
MST2 KRS1 |
| Also known as: |
STK3+STK4 Polyclonal Antibody |
| Other name: |
Anti-STK3+STK4 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
STK3+STK4 |
| Short name: |
Anti-STK3+STK4 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-serine/threonine kinase 3+serine/threonine kinase 4 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
KRS1 and MST2, KRS2 and MST1 and TIIAC and YSK3, STK3 and IDBG-30072 and ENSG00000104375 and 6788, STK3 and IDBG-645151 and ENSBTAG00000026234 and 533815, STK4 and IDBG-642847 and ENSBTAG00000003257 and 514886, STK4 and IDBG-77184 and ENSG00000101109 and 6789, Stk3 and IDBG-134139 and ENSMUSG00000022329 and 56274, Stk4 and IDBG-212019 and ENSMUSG00000018209 and 58231, nuclei, nuclei, serine/threonine kinase 4, this GO :0000287 and magnesium ion binding and molecular function this GO :0000902 and cell morphogenesis and biological process this GO :0001569 and patterning of blood vessels and biological process this GO :0001841 and neural tube formation and biological process this GO :0003157 and endocardium development and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006915 and apoptotic process and biological process this GO :0007165 and signal transduction and biological process this GO :0007417 and central nervous system development and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0016772 and transferase activity, this GO :0000287 and magnesium ion binding and molecular function this GO :0001841 and neural tube formation and biological process this GO :0003157 and endocardium development and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006915 and apoptotic process and biological process this GO :0007165 and signal transduction and biological process this GO :0007417 and central nervous system development and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0016772 and transferase activity, this GO :0000287 : magnesium ion binding, this GO :0000287 : magnesium ion binding, this GO :0000287 : magnesium ion binding and also this GO :0004672 : protein kinase activity and also this GO :0004674 : protein serine/threonine kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0008134 : transcription factor binding and also this GO :0016772 : transferase activity, this GO :0000287 : magnesium ion binding and also this GO :0004672 : protein kinase activity and also this GO :0004674 : protein serine/threonine kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, this GO :0004672 : protein kinase activity, this GO :0004672 : protein kinase activity, this GO :0004674 : protein serine/threonine kinase activity, this GO :0004674 : protein serine/threonine kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0005515 : protein binding, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0005524 : ATP binding, this GO :0008134 : transcription factor binding, this GO :0016772 : transferase activity, this GO :0016772 : transferase activity, this GO :0042802 : identical protein binding, this GO :0042803 : protein homodimerization activity, this GO :0043539 : protein serine/threonine kinase activator activity, this GO :0043539 : protein serine/threonine kinase activator activity, this GO :0046983 : protein dimerization activity, this GO :0046983 : protein dimerization activity, transferase activity, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0042802 : identical protein binding and also this GO :0042803 : protein homodimerization activity and also this GO :0043539 : protein serine/threonine kinase activator activity and also this GO :0046983 : protein dimerization activity, transferring phosphorus-containing groups and also this GO :0043539 : protein serine/threonine kinase activator activity and also this GO :0046983 : protein dimerization activity, transferring phosphorus-containing groups and molecular function this GO :0018105 and peptidyl-serine phosphorylation and biological process this GO :0023014 and signal transduction by phosphorylation and biological process this GO :0030216 and keratinocyte differentiation and biological process this GO :0035329 and hippo signaling and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0042802 and identical protein binding and molecular function this GO :0042803 and protein homodimerization activity and molecular function this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043539 and protein serine/threonine kinase activator activity and molecular function this GO :0046621 and negative regulation of organ growth and biological process this GO :0046777 and protein autophosphorylation and biological process this GO :0046983 and protein dimerization activity and molecular function this GO :0060215 and primitive hemopoiesis and biological process this GO :0060706 and cell differentiation involved in embryonic placenta development and biological process this GO :0071902 and positive regulation of protein serine/threonine kinase activity and biological process this GO :0090090 and negative regulation of canonical Wnt signaling pathway and biological process this GO :0097284 and hepatocyte apoptotic process and biological process this GO :1902043 and positive regulation of extrinsic apoptotic signaling pathway via death domain receptors and biological process, transferring phosphorus-containing groups and molecular function this GO :0023014 and signal transduction by phosphorylation and biological process this GO :0035329 and hippo signaling and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043539 and protein serine/threonine kinase activator activity and molecular function this GO :0046330 and positive regulation of JNK cascade and biological process this GO :0046621 and negative regulation of organ growth and biological process this GO :0046983 and protein dimerization activity and molecular function this GO :0051897 and positive regulation of protein kinase B signaling and biological process this GO :0060215 and primitive hemopoiesis and biological process this GO :0060706 and cell differentiation involved in embryonic placenta development and biological process this GO :0071902 and positive regulation of protein serine/threonine kinase activity and biological process this GO :0090090 and negative regulation of canonical Wnt signaling pathway and biological process this GO :0097284 and hepatocyte apoptotic process and biological process this GO :1902043 and positive regulation of extrinsic apoptotic signaling pathway via death domain receptors and biological process, serine/threonine kinase 3 |
| Identity: |
11406 |
| Gene: |
STK3 |
More about : STK3 |
| Long gene name: |
serine/threonine kinase 3 |
| Synonyms gene name: |
serine/threonine kinase 3 (Ste20, yeast homolog) |
| Locus: |
8q22, 2 |
| Discovery year: |
1997-10-09 |
| GenBank acession: |
BC010640 |
| Entrez gene record: |
6788 |
| Pubmed identfication: |
8816758 |
| RefSeq identity: |
NM_006281 |
| Havana BLAST/BLAT: |
OTTHUMG00000164651 |