| Long name: |
ALEXA FLUOR 555 Conjugated, STK3+STK4 Polyclonal Antibody |
| Also known as: |
Anti-STK3+STK4 PAb ALEXA FLUOR 555 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
555, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
STK3+STK4 |
| Specificity: |
This is a highly specific antibody against STK3+STK4 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
110-150/491 |
| Subcellular location: |
Helical |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human STK3 |
| Gene ID Number: |
6788, 6789 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis, The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation, following caspase-cleavage, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, pro-apoptotic kinase which, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ, Stress-activated |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
553nm/568nm |
| Synonyms: |
MST2 KRS1 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, Very high photo stable ALEXA conjugate, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 555, Alexa Fluor |
| Gene target: |
STK3+STK4 |
| Short name: |
STK3+STK4 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 555 |
| Alternative name: |
ALEXA FLUOR 555, serine/threonine kinase 3+serine/threonine kinase 4 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
KRS1 and MST2, KRS2 and MST1 and TIIAC and YSK3, STK3 and IDBG-30072 and ENSG00000104375 and 6788, STK3 and IDBG-645151 and ENSBTAG00000026234 and 533815, STK4 and IDBG-642847 and ENSBTAG00000003257 and 514886, STK4 and IDBG-77184 and ENSG00000101109 and 6789, Stk3 and IDBG-134139 and ENSMUSG00000022329 and 56274, Stk4 and IDBG-212019 and ENSMUSG00000018209 and 58231, nuclei, nuclei, serine/threonine kinase 4, this GO :0000287 and magnesium ion binding and molecular function this GO :0000902 and cell morphogenesis and biological process this GO :0001569 and patterning of blood vessels and biological process this GO :0001841 and neural tube formation and biological process this GO :0003157 and endocardium development and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006915 and apoptotic process and biological process this GO :0007165 and signal transduction and biological process this GO :0007417 and central nervous system development and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0016772 and transferase activity, this GO :0000287 and magnesium ion binding and molecular function this GO :0001841 and neural tube formation and biological process this GO :0003157 and endocardium development and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006915 and apoptotic process and biological process this GO :0007165 and signal transduction and biological process this GO :0007417 and central nervous system development and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0016772 and transferase activity, this GO :0000287 : magnesium ion binding, this GO :0000287 : magnesium ion binding, this GO :0000287 : magnesium ion binding and also this GO :0004672 : protein kinase activity and also this GO :0004674 : protein serine/threonine kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0008134 : transcription factor binding and also this GO :0016772 : transferase activity, this GO :0000287 : magnesium ion binding and also this GO :0004672 : protein kinase activity and also this GO :0004674 : protein serine/threonine kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, this GO :0004672 : protein kinase activity, this GO :0004672 : protein kinase activity, this GO :0004674 : protein serine/threonine kinase activity, this GO :0004674 : protein serine/threonine kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0005515 : protein binding, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0005524 : ATP binding, this GO :0008134 : transcription factor binding, this GO :0016772 : transferase activity, this GO :0016772 : transferase activity, this GO :0042802 : identical protein binding, this GO :0042803 : protein homodimerization activity, this GO :0043539 : protein serine/threonine kinase activator activity, this GO :0043539 : protein serine/threonine kinase activator activity, this GO :0046983 : protein dimerization activity, this GO :0046983 : protein dimerization activity, transferase activity, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0042802 : identical protein binding and also this GO :0042803 : protein homodimerization activity and also this GO :0043539 : protein serine/threonine kinase activator activity and also this GO :0046983 : protein dimerization activity, transferring phosphorus-containing groups and also this GO :0043539 : protein serine/threonine kinase activator activity and also this GO :0046983 : protein dimerization activity, transferring phosphorus-containing groups and molecular function this GO :0018105 and peptidyl-serine phosphorylation and biological process this GO :0023014 and signal transduction by phosphorylation and biological process this GO :0030216 and keratinocyte differentiation and biological process this GO :0035329 and hippo signaling and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0042802 and identical protein binding and molecular function this GO :0042803 and protein homodimerization activity and molecular function this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043539 and protein serine/threonine kinase activator activity and molecular function this GO :0046621 and negative regulation of organ growth and biological process this GO :0046777 and protein autophosphorylation and biological process this GO :0046983 and protein dimerization activity and molecular function this GO :0060215 and primitive hemopoiesis and biological process this GO :0060706 and cell differentiation involved in embryonic placenta development and biological process this GO :0071902 and positive regulation of protein serine/threonine kinase activity and biological process this GO :0090090 and negative regulation of canonical Wnt signaling pathway and biological process this GO :0097284 and hepatocyte apoptotic process and biological process this GO :1902043 and positive regulation of extrinsic apoptotic signaling pathway via death domain receptors and biological process, transferring phosphorus-containing groups and molecular function this GO :0023014 and signal transduction by phosphorylation and biological process this GO :0035329 and hippo signaling and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043539 and protein serine/threonine kinase activator activity and molecular function this GO :0046330 and positive regulation of JNK cascade and biological process this GO :0046621 and negative regulation of organ growth and biological process this GO :0046983 and protein dimerization activity and molecular function this GO :0051897 and positive regulation of protein kinase B signaling and biological process this GO :0060215 and primitive hemopoiesis and biological process this GO :0060706 and cell differentiation involved in embryonic placenta development and biological process this GO :0071902 and positive regulation of protein serine/threonine kinase activity and biological process this GO :0090090 and negative regulation of canonical Wnt signaling pathway and biological process this GO :0097284 and hepatocyte apoptotic process and biological process this GO :1902043 and positive regulation of extrinsic apoptotic signaling pathway via death domain receptors and biological process, serine/threonine kinase 3 |
| Identity: |
11406 |
| Gene: |
STK3 |
More about : STK3 |
| Long gene name: |
serine/threonine kinase 3 |
| Synonyms gene name: |
serine/threonine kinase 3 (Ste20, yeast homolog) |
| Locus: |
8q22, 2 |
| Discovery year: |
1997-10-09 |
| GenBank acession: |
BC010640 |
| Entrez gene record: |
6788 |
| Pubmed identfication: |
8816758 |
| RefSeq identity: |
NM_006281 |
| Havana BLAST/BLAT: |
OTTHUMG00000164651 |