| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
CARD8 |
| Specificity: |
This antibody reacts specifically with CARD8 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human CARD8 |
| Gene ID: |
22900 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
May be a component of the inflammasome, May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases, a protein complex which also includes PYCARD, Inhibits NF-kappa-B activation |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
TUCAN KIAA0955 CARDINAL NDPP Dakar |
| Also known as: |
CARD8 Polyclonal Antibody |
| Other name: |
Anti-CARD8 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
CARD8 |
| Short name: |
Anti-CARD8 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, member 8 (polyclonal), antibody to-caspase recruitment domain family |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
CARD8 and IDBG-60120 and ENSG00000105483 and 22900, CARDINAL and DACAR and DAKAR and NDPP and NDPP1 and TUCAN, member 8, nuclei, protein homodimerization activity, this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0006919 and activation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0008656 and cysteine-type endopeptidase activator activity involved in apoptotic process and molecular function this GO :0032089 and NACHT domain binding and molecular function this GO :0042803 and protein homodimerization activity and molecular function this GO :0042981 and regulation of apoptotic process and biological process this GO :0043124 and negative regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0043280 and positive regulation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0050718 and positive regulation of interleukin-1 beta secretion and biological process this GO :0072559 and NLRP3 inflammasome complex and cellular component, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0008656 : cysteine-type endopeptidase activator activity involved in apoptotic process and also this GO :0032089 : NACHT domain binding and also this GO :0042803 : protein homodimerization activity, this GO :0008656 : cysteine-type endopeptidase activator activity involved in apoptotic process, this GO :0032089 : NACHT domain binding, this GO :0042803 : protein homodimerization activity, caspase recruitment domain family |
| Identity: |
17057 |
| Gene: |
CARD8 |
More about : CARD8 |
| Long gene name: |
caspase recruitment domain family member 8 |
| Synonyms gene name: |
caspase recruitment domain family, member 8 |
| Locus: |
19q13, 33 |
| Discovery year: |
2003-12-03 |
| GenBank acession: |
AB023172 |
| Entrez gene record: |
22900 |
| Pubmed identfication: |
10231032 11408476 |
| RefSeq identity: |
NM_014959 |
| Classification: |
Caspase recruitment domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000165047 |