| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
RAB7 |
| Specificity: |
This antibody reacts specifically with RAB7 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human RAB7 |
| Gene ID: |
7879 |
| Swiss Prot: |
P51149 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Also involved in regulation of some specialized endosomal membrane trafficking, Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA, Governs early-to-late endosomal maturation, In concert with RAC1, Microbial pathogens possess survival strategies governed by RAB7A, Mycobacterium), Plays a central role, Plays a role in the fusion of phagosomes with lysosomes, Plays a role in the maturation and acidification of phagosomes that engulf pathogens, Plays important roles in microbial pathogen infection and survival, Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation, Salmonella) and sometimes by excluding RAB7A function (e, and endosome-lysosome transport through different protein-protein interaction cascades, as well as in participating in the life cycle of viruses, but also in many other cellular and physiological events, microtubule minus-end as well as plus-end directed endosomal migration and positioning, neurotrophin transport in the axons of neurons and lipid metabolism, not only in endosomal traffic, nutrient-transportor mediated nutrient uptake, pathogen-induced phagosomes (or vacuoles) and autophagosomes, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts, sometimes by employing RAB7A function (e, such as S, such as growth-factor-mediated cell signaling, such as maturation of melanosomes, Key regulator in endo-lysosomal trafficking, aureus and M, g, g, tuberculosis |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Also known as: |
RAB7 Polyclonal Antibody |
| Other name: |
Anti-RAB7 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
RAB7 |
| Short name: |
Anti-RAB7 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-RAB7 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
9788 |
| Gene: |
RAB7A |
More about : RAB7A |
| Long gene name: |
RAB7A, member RAS oncogene family |
| Synonyms gene: |
RAB7 |
| Synonyms gene name: |
RAB7, member RAS oncogene family |
| Locus: |
3q21, 3 |
| Discovery year: |
1999-03-24 |
| GenBank acession: |
X93499 |
| Entrez gene record: |
7879 |
| Pubmed identfication: |
9126495 9428630 |
| Classification: |
RAB, member RAS oncogene GTPases |
| Havana BLAST/BLAT: |
OTTHUMG00000159812 |
| Locus Specific Databases: |
LRG_266 |