| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Emerin |
| Specificity: |
This antibody reacts specifically with Emerin |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Emerin |
| Gene ID: |
2010 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway, Association of EMD with the viral DNA requires the presence of BAF and viral integrase, EMD and BAF are cooperative cofactors of HIV-1 infection, Inhibits beta-catenin activity by preventing its accumulation in the nucleus, Links centrosomes to the nuclear envelope via a microtubule association, Required for proper localization of non-farnesylated prelamin-A/C, Skeletal muscle, Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments, The association of viral DNA with chromatin requires the presence of BAF and EMD, colon, heart, ovary and pancreas, testis, Stabilizes and promotes the formation of a nuclear actin cortical network, Tissue specificity |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
STA LEMD5 |
| Also known as: |
Emerin Polyclonal Antibody |
| Other name: |
Anti-Emerin Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Emerin |
| Short name: |
Anti-Emerin (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Emerin (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
3331 |
| Gene: |
EMD |
More about : EMD |
| Long gene name: |
emerin |
| Synonyms gene name: |
Emery-Dreifuss muscular dystrophy |
| Synonyms name: |
LEM domain containing 5 |
| Locus: |
Xq28 |
| Discovery year: |
2001-06-22 |
| GenBank acession: |
X82434 |
| Entrez gene record: |
2010 |
| Classification: |
LEM domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000033186 |
| Locus Specific Databases: |
Leiden Muscular Dystrophy Pages UMD Locus Specific Databases Leiden Muscular Dystrophy pages Mental Retardation database LRG_745 |