| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Emerin |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, Immunohistochemistry (FFPE): 1-2ug/ml, Western blot: 0 |
| Notes: |
Optimal dilution of the Emerin antibody should be determined by the researcher |
| Added buffer: |
025% sodium azide, 5% BSA and 0, Lyophilized from 1X Phosphate Buffered Saline (PBS) with 2 |
| Intented use: |
This antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P50402 |
| Purity: |
Antigen affinity |
| Description: |
And this gene is mapped to Xq28, Emerin appears to be involved in mechanotransduction, Emerin is a member of the nuclear lamina-associated protein family, Emery&ndash, In cardiac muscle, It mediates membrane anchorage to the cytoskeleton, This interaction appears to be regulated by glycogen synthase kinase 3 beta, and cardiomyocytes from hearts lacking emerin showed beta-catenin redistribution as well as perturbed intercalated disc architecture and myocyte shape, as emerin-deficient mouse fibroblasts failed to transduce normal mechanosensitive gene expression responses to strain stimuli, emerin is also found complexed to beta-catenin at adherens junctions of intercalated discs, Dreifuss muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the EMD (also known clinically as STA) gene, Emerin is a serine-rich nuclear membrane protein that in humans is encoded by the EMD gene |
| Immunogen: |
Amino acids 1-48 (MDNYADLSDTELTTLLRRYNIPHGPVVGSTRRLYEKKIFEYETQRRRL-human) were used as the immunogen for the Emerin antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the Emerin antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term |
| Localization: |
nuclear, Nuclear membrane |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
Emerin |
| Short name: |
Emerin Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Emerin (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
3331 |
| Gene: |
EMD |
More about : EMD |
| Long gene name: |
emerin |
| Synonyms gene name: |
Emery-Dreifuss muscular dystrophy |
| Synonyms: |
STA LEMD5 |
| Synonyms name: |
LEM domain containing 5 |
| Locus: |
Xq28 |
| Discovery year: |
2001-06-22 |
| GenBank acession: |
X82434 |
| Entrez gene record: |
2010 |
| Classification: |
LEM domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000033186 |
| Locus Specific Databases: |
Leiden Muscular Dystrophy Pages UMD Locus Specific Databases Leiden Muscular Dystrophy pages Mental Retardation database LRG_745 |