| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
RORG |
| Specificity: |
This antibody reacts specifically with RORG |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Nucleus |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human RORG |
| Gene ID: |
6097 |
| Swiss Prot: |
P51449 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
ARNTL/BMAL1 and NR1D1 in peripheral tissues and in a tissue-selective manner, CRY1 and NR1D1 itself, Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as ARNTL/BMAL1, Considered to have intrinsic transcriptional activity, Controls adipogenesis as well as adipocyte size and modulates insulin sensitivity in obesity, In liver, Involved in the regulation of the rhythmic expression of genes involved in glucose and lipid metabolism, Key regulator of cellular differentiation, Negative regulator of adipocyte differentiation through the regulation of early phase genes expression, Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, Regulates the circadian expression of clock genes such as CRY1, Therefore influences the period length and stability of the clock, depending on the tissue, enhancing or repressing the transcriptional activity, has specific and redundant functions with RORA as positive or negative modulator of expression of genes encoding phase I and Phase II proteins involved in the metabolism of lipids, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), immunity, including PLIN2 and AVPR1A, leading to the circadian pattern of clock genes expression, peripheral circadian rhythm as well as lipid, respectively, resulting in NR1D1-mediated repression or RORC-mediated activation of the expression, steroid, steroids and xenobiotics, such as MMP3, such as SULT1E1, time and promoter contexts, xenobiotics and glucose metabolism, Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
RZRG RORG NR1F3 TOR |
| Also known as: |
RORG Polyclonal Antibody |
| Other name: |
Anti-RORG Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
RORG |
| Short name: |
Anti-RORG (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-RORG (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
10260 |
| Gene: |
RORC |
More about : RORC |
| Long gene name: |
RAR related orphan receptor C |
| Synonyms gene name: |
RAR-related orphan receptor C |
| Locus: |
1q21 |
| Discovery year: |
1995-04-13 |
| GenBank acession: |
U16997 |
| Pubmed identfication: |
7811290 |
| Classification: |
Nuclear hormone receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000013053 |