| Long name: |
RORG Primary Polyclonal Antibody |
| Also known as: |
RORG PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
RORG |
| Specificity: |
This is a highly specific antibody against RORG |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
440-490/518 |
| Subcellular location: |
Nucleus |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human RORG |
| Gene ID number: |
6097 |
| Swiss Prot: |
P51449 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
ARNTL/BMAL1 and NR1D1 in peripheral tissues and in a tissue-selective manner, CRY1 and NR1D1 itself, Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as ARNTL/BMAL1, Considered to have intrinsic transcriptional activity, Controls adipogenesis as well as adipocyte size and modulates insulin sensitivity in obesity, In liver, Involved in the regulation of the rhythmic expression of genes involved in glucose and lipid metabolism, Key regulator of cellular differentiation, Negative regulator of adipocyte differentiation through the regulation of early phase genes expression, Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, Regulates the circadian expression of clock genes such as CRY1, Therefore influences the period length and stability of the clock, depending on the tissue, enhancing or repressing the transcriptional activity, has specific and redundant functions with RORA as positive or negative modulator of expression of genes encoding phase I and Phase II proteins involved in the metabolism of lipids, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), immunity, including PLIN2 and AVPR1A, leading to the circadian pattern of clock genes expression, peripheral circadian rhythm as well as lipid, respectively, resulting in NR1D1-mediated repression or RORC-mediated activation of the expression, steroid, steroids and xenobiotics, such as MMP3, such as SULT1E1, time and promoter contexts, xenobiotics and glucose metabolism, Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
NR1F3, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group F member 3, RAR-related orphan receptor C, RORC, RORG, RZR-GAMMA, RZRG, Retinoid-related orphan receptor-gamma, TOR |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
RORG |
| Short name: |
RORG Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
RORG (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
10260 |
| Gene: |
RORC |
More about : RORC |
| Long gene name: |
RAR related orphan receptor C |
| Synonyms gene name: |
RAR-related orphan receptor C |
| Synonyms: |
RZRG RORG NR1F3 TOR |
| Locus: |
1q21 |
| Discovery year: |
1995-04-13 |
| GenBank acession: |
U16997 |
| Pubmed identfication: |
7811290 |
| Classification: |
Nuclear hormone receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000013053 |