| Long name: |
Biotin Conjugated, RORG Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
RORG |
| Specificity: |
This is a highly specific antibody against RORG |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
440-490/518 |
| Subcellular location: |
Nucleus |
| Source: |
KLH conjugated synthetic peptide derived from human RORG |
| Gene ID number: |
6097 |
| Swiss Prot: |
P51449 |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
ARNTL/BMAL1 and NR1D1 in peripheral tissues and in a tissue-selective manner, CRY1 and NR1D1 itself, Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as ARNTL/BMAL1, Considered to have intrinsic transcriptional activity, Controls adipogenesis as well as adipocyte size and modulates insulin sensitivity in obesity, In liver, Involved in the regulation of the rhythmic expression of genes involved in glucose and lipid metabolism, Key regulator of cellular differentiation, Negative regulator of adipocyte differentiation through the regulation of early phase genes expression, Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, Regulates the circadian expression of clock genes such as CRY1, Therefore influences the period length and stability of the clock, depending on the tissue, enhancing or repressing the transcriptional activity, has specific and redundant functions with RORA as positive or negative modulator of expression of genes encoding phase I and Phase II proteins involved in the metabolism of lipids, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), immunity, including PLIN2 and AVPR1A, leading to the circadian pattern of clock genes expression, peripheral circadian rhythm as well as lipid, respectively, resulting in NR1D1-mediated repression or RORC-mediated activation of the expression, steroid, steroids and xenobiotics, such as MMP3, such as SULT1E1, time and promoter contexts, xenobiotics and glucose metabolism, Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
RZRG RORG NR1F3 TOR |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
RORG Conjugated |
| Short name: |
Conjugated, RORG Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, RORG (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
10260 |
| Gene: |
RORC |
More about : RORC |
| Long gene name: |
RAR related orphan receptor C |
| Synonyms gene name: |
RAR-related orphan receptor C |
| Locus: |
1q21 |
| Discovery year: |
1995-04-13 |
| GenBank acession: |
U16997 |
| Pubmed identfication: |
7811290 |
| Classification: |
Nuclear hormone receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000013053 |