| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
RbAp48 |
| Specificity: |
This antibody reacts specifically with RbAp48 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human RbAp48 |
| Gene ID: |
5928 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
It is also a component of the DREAM complex, RpAp48 also interacts with the retinoblastoma protein, These complexes include Chromatin Assembly Factor 1 (CAF1), and histone deacetylation, and the PRC2 complex, and with SPEN/MINT and BRCA1, chromatin remodeling, the core histone deacetylase (HDAC) complex, the nucleosome remodeling and histone deacetylation complex NuRD, the nucleosome remodeling factor (NURF) complex, which is required for chromatin assembly following DNA replication and repair, which promotes histone deacetylation and subsequent transcriptional repression, which promotes repression of homeotic genes during development, which represses cell cycle-dependent genes in quiescent cells, RbAp48 (Retinoblastoma-binding protein p48 or Rb-associated protein p48)is a WD repeat protein that is a core histone binding subunit common to several complexes involved in chromatin assembly |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
RbAp48 NURF55 lin-53 |
| Also known as: |
RbAp48 Polyclonal Antibody |
| Other name: |
Anti-RbAp48 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
RbAp48 |
| Short name: |
Anti-RbAp48 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-RbAp48 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
9887 |
| Gene: |
RBBP4 |
More about : RBBP4 |
| Long gene name: |
RB binding protein 4, chromatin remodeling factor |
| Synonyms gene name: |
retinoblastoma-binding protein 4 retinoblastoma binding protein 4 |
| Locus: |
1p35, 1 |
| Discovery year: |
1995-05-05 |
| GenBank acession: |
BC053904 |
| Entrez gene record: |
5928 |
| Pubmed identfication: |
8350924 14609955 17531812 |
| RefSeq identity: |
NM_005610 |
| Classification: |
NuRD complex Polycomb repressive complex 2 EMSY complex SIN3 histone deacetylase complex WD repeat domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000007998 |