| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
AXL |
| Specificity: |
This antibody reacts specifically with AXL |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human AXL |
| Gene ID: |
558 |
| Swiss Prot: |
P30530 |
| Applications: |
IF(IHC-P), FCM |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200), FCM(1:20-100) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, Following activation by ligand, GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, In case of filovirus infection, LCK and PTPN11, Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL, NCK2, Other downstream substrate candidates for AXL are CBL, PIK3R2 and PIK3R3, PLCG1, Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response, Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase, SOCS1 and TENC1, but also GRB2, cell proliferation, gonadotropin-releasing hormone neuron survival and migration, hepatic regeneration, migration and differentiation, optimal cytokine signaling during human natural killer cell development, or regulation of thrombotic responses, platelet activation, seems to function as a cell entry factor, Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
UFO JTK11 Tyro7 ARK |
| Also known as: |
AXL Polyclonal Antibody |
| Other name: |
Anti-AXL Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
AXL |
| Short name: |
Anti-AXL (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-AXL (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
905 |
| Gene: |
AXL |
More about : AXL |
| Long gene name: |
AXL receptor tyrosine kinase |
| Locus: |
19q13, 2 |
| Discovery year: |
1992-09-15 |
| GenBank acession: |
M76125 |
| Entrez gene record: |
558 |
| Pubmed identfication: |
1656220 |
| Classification: |
Immunoglobulin like domain containing V-set domain containing Fibronectin type III domain containing Receptor Tyrosine Kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000182727 |