| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
AXL Tyr698+Tyr702+Tyr703 |
| Specificity: |
This antibody reacts specifically with AXL (Tyr698+Tyr702+Tyr703) |
| Modification: |
Phosphorylation |
| Modification site: |
Tyr698+Tyr702+Tyr703 |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic phosphopeptide derived from human AXL around the phosphorylation site of Tyr698+Tyr702+Tyr703 |
| Gene ID: |
558 |
| Applications: |
IF(IHC-P), FCM |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200), FCM(1:20-100) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Although it is similar to other receptor tyrosine kinases, Axl is a chronic myelogenous leukemia associated oncogene and also associated with colon cancer and melanoma, It is involved in the stimulation of cell proliferation, It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors such as vitamin K dependent protein growth arrest specific gene 6, This gene has two different alternatively spliced transcript variants (AXL1 and AXL2), This receptor can also mediate cell aggregation by homophilic binding, the Axl protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats, The Axl gene is evolutionarily conserved between vertebrate species, The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
UFO JTK11 Tyro7 ARK |
| Also known as: |
AXL (Tyr698+Tyr702+Tyr703) Antibody |
| Other name: |
Anti-AXL (Tyr698+Tyr702+Tyr703) |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
AXL (Tyr698+Tyr702+Tyr703) |
| Short name: |
Anti-AXL (Tyr698+Tyr702+Tyr703) Fluor 594 |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-AXL (Tyr698+Tyr702+Tyr703) |
| Identity: |
905 |
| Gene: |
AXL |
More about : AXL |
| Long gene name: |
AXL receptor tyrosine kinase |
| Locus: |
19q13, 2 |
| Discovery year: |
1992-09-15 |
| GenBank acession: |
M76125 |
| Entrez gene record: |
558 |
| Pubmed identfication: |
1656220 |
| Classification: |
Immunoglobulin like domain containing V-set domain containing Fibronectin type III domain containing Receptor Tyrosine Kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000182727 |