| Long name: |
ALEXA FLUOR 350 Conjugated, AXL Polyclonal Antibody |
| Also known as: |
Anti-AXL PAb ALEXA FLUOR 350 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
350, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
AXL |
| Specificity: |
This is a highly specific antibody against AXL |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
180-230/894 |
| Subcellular location: |
Extracellular |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human AXL |
| Gene ID Number: |
558 |
| Swiss Prot: |
P30530 |
| Tested applications: |
IF(IHC-P), FCM |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), FCM(1:20-100) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, Following activation by ligand, GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, In case of filovirus infection, LCK and PTPN11, Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL, NCK2, Other downstream substrate candidates for AXL are CBL, PIK3R2 and PIK3R3, PLCG1, Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response, Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase, SOCS1 and TENC1, but also GRB2, cell proliferation, gonadotropin-releasing hormone neuron survival and migration, hepatic regeneration, migration and differentiation, optimal cytokine signaling during human natural killer cell development, or regulation of thrombotic responses, platelet activation, seems to function as a cell entry factor, Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
343nm/442nm |
| Synonyms: |
UFO JTK11 Tyro7 ARK |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 350, Alexa Fluor |
| Gene target: |
AXL |
| Short name: |
AXL Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 350 |
| Alternative name: |
ALEXA FLUOR 350, AXL (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
905 |
| Gene: |
AXL |
More about : AXL |
| Long gene name: |
AXL receptor tyrosine kinase |
| Locus: |
19q13, 2 |
| Discovery year: |
1992-09-15 |
| GenBank acession: |
M76125 |
| Entrez gene record: |
558 |
| Pubmed identfication: |
1656220 |
| Classification: |
Immunoglobulin like domain containing V-set domain containing Fibronectin type III domain containing Receptor Tyrosine Kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000182727 |