| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Chondroitin sulfate proteoglycan NG2 |
| Specificity: |
This antibody reacts specifically with Chondroitin sulfate proteoglycan NG2 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Chondroitin sulfate proteoglycan NG2 |
| Gene ID: |
1464 |
| Swiss Prot: |
Q6UVK1 |
| Applications: |
IF(IHC-P), FCM |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200), FCM(1:20-100) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
ACK1 and BCAR1, Binds through its extracellular N-terminus growth factors, Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate, Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins, May activate FAK and ERK1/ERK2 signaling cascades, May also inhibit neurite outgrowth and growth cone collapse during axon regeneration, May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin, May promote retraction fiber formation and cell polarization through Rho GTPase activation, May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties, May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, extracellular matrix proteases modulating their activity, Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
NG2 G16 RING5 RMA1 |
| Also known as: |
Chondroitin sulfate proteoglycan NG2 Antibody |
| Other name: |
Anti-Chondroitin sulfate proteoglycan NG2 |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
Chondroitin sulfate proteoglycan NG2 |
| Short name: |
Fluor 594, Anti-Chondroitin sulfate proteoglycan NG2 |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Chondroitin sulfate proteoglycan NG2 |
| Identity: |
10068 |
| Gene: |
RNF5 |
More about : RNF5 |
| Long gene name: |
ring finger protein 5 |
| Synonyms gene name: |
E3 ubiquitin protein ligase , ring finger protein 5 |
| Locus: |
6p21, 32 |
| Discovery year: |
1997-10-16 |
| GenBank acession: |
U89336 |
| Entrez gene record: |
6048 |
| Pubmed identfication: |
9533025 |
| RefSeq identity: |
NM_006913 |
| Classification: |
Ring finger proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000031093 |